CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011731
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bone marrow stromal antigen 2 
Protein Synonyms/Alias
 BST-2; HM1.24 antigen; Tetherin; CD317 
Gene Name
 BST2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18VPMEDGDKRCKLLLGubiquitination[1]
112EKAQGQKKVEELEGEubiquitination[2]
126EITTLNHKLQDASAEubiquitination[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason- Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma- associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. 
Sequence Annotation
 LIPID 161 161 GPI-anchor amidated serine (Potential).
 CARBOHYD 65 65 N-linked (GlcNAc...).
 CARBOHYD 92 92 N-linked (GlcNAc...).
 DISULFID 53 53 Interchain.
 DISULFID 63 63 Interchain.
 DISULFID 91 91 Interchain.
 CROSSLNK 18 18 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Antiviral defense; B-cell activation; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Disulfide bond; Endosome; Glycoprotein; Golgi apparatus; GPI-anchor; Immunity; Innate immunity; Isopeptide bond; Lipoprotein; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 180 AA 
Protein Sequence
MASTSYDYCR VPMEDGDKRC KLLLGIGILV LLIIVILGVP LIIFTIKANS EACRDGLRAV 60
MECRNVTHLL QQELTEAQKG FQDVEAQAAT CNHTVMALMA SLDAEKAQGQ KKVEELEGEI 120
TTLNHKLQDA SAEVERLRRE NQVLSVRIAD KKYYPSSQDS SSAAAPQLLI VLLGLSALLQ 180 
Gene Ontology
 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
 GO:0009986; C:cell surface; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
 GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
 GO:0008191; F:metalloendopeptidase inhibitor activity; IDA:UniProtKB.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0051607; P:defense response to virus; IDA:UniProtKB.
 GO:0006959; P:humoral immune response; TAS:ProtInc.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:0030336; P:negative regulation of cell migration; IDA:UniProtKB.
 GO:1901253; P:negative regulation of egress of virus within host cell; IDA:UniProtKB.
 GO:0002737; P:negative regulation of plasmacytoid dendritic cell cytokine production; IDA:UniProtKB.
 GO:0045071; P:negative regulation of viral genome replication; IDA:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
 GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.
 GO:0035455; P:response to interferon-alpha; ISS:UniProtKB.
 GO:0035456; P:response to interferon-beta; ISS:UniProtKB.
 GO:0034341; P:response to interferon-gamma; ISS:UniProtKB. 
Interpro
 IPR024886; BST2. 
Pfam
  
SMART
  
PROSITE
  
PRINTS