UniProt Accession

 IRK16_RAT; P52191; Q9JI87 

Genbank Protein ID

 X83581; AF249676 

Genbank Nucleotide ID

 CAA58564.1; AAF74265.1 

Protein Name

 Inward rectifier potassium channel 16 

Protein Synonyms/Alias

 BIR9; Inward rectifier K(+) channel Kir5.1; Potassium channel, inwardly rectifying subfamily J member 16 

Gene Name

 Kcnj16 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
317	FHDVLEVKRKYYKVN	acetylation	[1]
347	SAKQLDWKDQQLNNL	acetylation	[1]
347	SAKQLDWKDQQLNNL	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance (By similarity). 

Sequence Annotation

 MOTIF 131 136 Selectivity filter (By similarity).  

Keyword

 Complete proteome; Ion channel; Ion transport; Membrane; Potassium; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 419 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro. 

Interpro

 IPR014756; Ig_E-set.
 IPR016449; K_chnl_inward-rec_Kir.
 IPR008061; K_chnl_inward-rec_Kir5.
 IPR013518; K_chnl_inward-rec_Kir_cyto. 

Pfam

 PF01007; IRK 

SMART

  

PROSITE

  

PRINTS

 PR01678; KIR5CHANNEL.
 PR01320; KIRCHANNEL.