| Tag | Content |
|---|
| CPLM ID | CPLM-022584 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vesicular glutamate transporter 2 |
Protein Synonyms/Alias | VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 |
Gene Name | SLC17A6 |
Gene Synonyms/Alias | DNPI; VGLUT2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 109 | STIHRGGKVIKEKAK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. |
Sequence Annotation | CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
CARBOHYD 101 101 N-linked (GlcNAc...) (Potential).
CARBOHYD 470 470 N-linked (GlcNAc...) (Potential). |
Keyword | Cell junction; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Ion transport; Membrane; Neurotransmitter transport; Polymorphism; Reference proteome; Sodium; Sodium transport; Symport; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 582 AA |
Protein Sequence | MESVKQRILA PGKEGLKNFA GKSLGQIYRV LEKKQDTGET IELTEDGKPL EVPERKAPLC 60
DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN NSTIHRGGKV IKEKAKFNWD 120
PETVGMIHGS FFWGYIITQI PGGYIASRLA ANRVFGAAIL LTSTLNMLIP SAARVHYGCV 180
IFVRILQGLV EGVTYPACHG IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT 240
GWSSVFYVYG SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK 300
TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM LSAVPHLVMT 360
IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL LVVGYSHTRG VAISFLVLAV 420
GFSGFAISGF NVNHLDIAPR YASILMGISN GVGTLSGMVC PIIVGAMTKN KSREEWQYVF 480
LIAALVHYGG VIFYAIFASG EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT 540
TKSYGATTQA NGGWPSGWEK KEEFVQGEVQ DSHSYKDRVD YS 582 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell. GO:0030672; C:synaptic vesicle membrane; TAS:Reactome. GO:0005313; F:L-glutamate transmembrane transporter activity; IEA:Compara. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0015813; P:L-glutamate transport; IEA:GOC. GO:0001504; P:neurotransmitter uptake; IEA:Compara. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. GO:0055085; P:transmembrane transport; TAS:Reactome. |
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PROSITE | |
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