CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027478
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic translation initiation factor 2 gamma subunit, putative 
Protein Synonyms/Alias
  
Gene Name
 PF14_0104 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
190QNKVELIKEEQALKQacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Initiation factor; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 465 AA 
Protein Sequence
MNINEKDKLA EQNLETLDVT KLTPLSEDVI SRQATINLGT IGHVAHGKST LVHAISGVHT 60
VRFKHEKERN ITIKLGYANA KIYKCTNPDC LPPECYKSYE SSKEDNPICP RKDCNHEMKL 120
LRHVSFVDCP GHDILMATML NGAAVMDAAL LLVAGNESCP QPQTSEHLAA VEIMRLKHIL 180
ILQNKVELIK EEQALKQQEE IRNFVSGTAA DSAPIIPISA VLKYNIDVVC EYIVTQISIP 240
KRDFISSPHM IVIRSFDVNK PGEDIETLQG GVAGGSILHG VLKVGDKIEI RPGIISKDDK 300
GEITCRPIIS QILSMFAENN NLKYAVPGGL IGVGTKIDPI LTRADRLVGQ VIGHLNKLPD 360
CFAEIEISYY LLRRLLGVKS QDGEKNTKVA KLKNGEFLMI NIGSTSIGCR VTGIKTELAK 420
LELTGPVCTK IGDKIALSRR VDKHWRLIGW GQINKGKPLE LQEPI 465 
Gene Ontology
 GO:0005850; C:eukaryotic translation initiation factor 2 complex; ISS:GeneDB_Pfalciparum.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0006413; P:translational initiation; ISS:GeneDB_Pfalciparum. 
Interpro
 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR015256; TIF2_gsu_C.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF09173; eIF2_C
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2 
SMART
  
PROSITE
  
PRINTS
 PR00315; ELONGATNFCT.