CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002421
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 6-phosphofructokinase isozyme 2 
Protein Synonyms/Alias
 Phosphofructokinase-2 
Gene Name
 pfkB 
Gene Synonyms/Alias
 b1723; JW5280 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
27PQIYPEGKLRCTAPVacetylation[1]
148PPGVKLEKLTQLISAacetylation[1]
158QLISAAQKQGIRCIVacetylation[1]
189ELVKPNQKELSALVNacetylation[1]
302CSHDDTQKIYAYLSRacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
  
Keyword
 3D-structure; ATP-binding; Complete proteome; Glycolysis; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 309 AA 
Protein Sequence
MVRIYTLTLA PSLDSATITP QIYPEGKLRC TAPVFEPGGG GINVARAIAH LGGSATAIFP 60
AGGATGEHLV SLLADENVPV ATVEAKDWTR QNLHVHVEAS GEQYRFVMPG AALNEDEFRQ 120
LEEQVLEIES GAILVISGSL PPGVKLEKLT QLISAAQKQG IRCIVDSSGE ALSAALAIGN 180
IELVKPNQKE LSALVNRELT QPDDVRKAAQ EIVNSGKAKR VVVSLGPQGA LGVDSENCIQ 240
VVPPPVKSQS TVGAGDSMVG AMTLKLAENA SLEEMVRFGV AAGSAATLNQ GTRLCSHDDT 300
QKIYAYLSR 309 
Gene Ontology
 GO:0003872; F:6-phosphofructokinase activity; IDA:EcoCyc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IDA:EcoCyc.
 GO:0009024; F:tagatose-6-phosphate kinase activity; IDA:EcoCyc.
 GO:0006096; P:glycolysis; IMP:EcoCyc.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. 
Interpro
 IPR002173; Carboh/pur_kinase_PfkB_CS.
 IPR011611; PfkB_dom.
 IPR017583; Tagatose/fructose_Pkinase. 
Pfam
 PF00294; PfkB 
SMART
  
PROSITE
 PS00583; PFKB_KINASES_1
 PS00584; PFKB_KINASES_2 
PRINTS