CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044159
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Derlin-2 
Protein Synonyms/Alias
  
Gene Name
 DERL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
119PGGIRILKTPSILKAubiquitination[1, 2]
125LKTPSILKAIFDTPDubiquitination[3, 4]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 158 AA 
Protein Sequence
WRLITNFLFF GPVGFNFLFN MIFLYRYCRM LEEGSFRGRT ADFVFMFLFG GFLMTQSDRM 60
SKSKELLTQA PFLPWVLMGF SLLLGNSIIV DLLGIAVGHI YFFLEDVFPN QPGGIRILKT 120
PSILKAIFDT PDEDPNYNPL PEERPGGFAW GEGQRLGG 158 
Gene Ontology
  
Interpro
 IPR007599; DER1. 
Pfam
 PF04511; DER1 
SMART
  
PROSITE
  
PRINTS