CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010599
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein pangolin, isoforms A/H/I 
Protein Synonyms/Alias
 dTCF 
Gene Name
 pan 
Gene Synonyms/Alias
 TCF; CG34403 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
25TDEVKIFKDEGDREDacetylation[1]
Reference
 [1] Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling.
 Waltzer L, Bienz M.
 Nature. 1998 Oct 1;395(6701):521-5. [PMID: 9774110] 
Functional Description
 Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes. 
Sequence Annotation
 DNA_BIND 273 341 HMG box.
 REGION 1 53 Beta-catenin binding site (By
 MOTIF 351 357 Nuclear localization signal (Potential).  
Keyword
 Activator; Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Nucleus; Reference proteome; Repressor; Segmentation polarity protein; Transcription; Transcription regulation; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 751 AA 
Protein Sequence
MPHTHSRHGS SGDDLCSTDE VKIFKDEGDR EDEKISSENL LVEEKSSLID LTESEEKGHK 60
ISRPDHSPVF NKLDTHAPSF NMGYLVSPYS YANGSPSGLP VTMANKIGLP PFFCHNADPL 120
STPPPAHCGI PPYQLDPKMG LTRPALYPFA GGQYPYPMLS SDMSQVASWH TPSVYSASSF 180
RTPYPSSLPI NTTLASDFPF RFSPSLLPSV HATSHHVINA HSAIVGVSSK QECGVQDPTT 240
NNRYPRNLEA KHTSNAQSNE SKETTNDKKK PHIKKPLNAF MLYMKEMRAK VVAECTLKES 300
AAINQILGRR WHELSREEQS KYYEKARQER QLHMELYPGW SARDNYGYVS KKKKRKKDRS 360
TTDSGGNNMK KCRARFGLDQ QSQWCKPCRR KKKCIRYMEA LNGNGPAEDG SCFDEHGSQL 420
SDDDEDDYDD DKLGGSCGSA DETNKIEDED SESLNQSMPS PGCLSGLSSL QSPSTTMSLA 480
SPLNMNANSA TNVIFPASSN ALLIVGADQP TAQQRPTLVS TSGSSSGSTS SISTTPNTSS 540
TVSPVTCMTG PCLGSSQERA MMLGNRFSHL GMGLSPPVVS TSTSKSEPFF KPHPTVCNNP 600
IFALPSIGNC SLNISSMPNT SRNPIGANPR DINNPLSINQ LTKRREYKNV ELIEASESKT 660
IVAHAATSII QHVAVNGYHA NHSLLNSNLG HLHHQLNNRT ENPNRSEQTM LSVSNHSVNS 720
SECHKESDSQ AIVSSNPPNA GSSDNGVISV S 751 
Gene Ontology
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005667; C:transcription factor complex; IPI:FlyBase.
 GO:0008013; F:beta-catenin binding; IBA:RefGenome.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:FlyBase.
 GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IBA:RefGenome.
 GO:0009880; P:embryonic pattern specification; IMP:FlyBase.
 GO:0007507; P:heart development; IMP:FlyBase.
 GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
 GO:0007500; P:mesodermal cell fate determination; TAS:FlyBase.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; NAS:FlyBase.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:FlyBase.
 GO:0045610; P:regulation of hemocyte differentiation; IMP:FlyBase.
 GO:0072091; P:regulation of stem cell proliferation; IMP:FlyBase.
 GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.
 GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
 GO:0035277; P:spiracle morphogenesis, open tracheal system; IMP:FlyBase. 
Interpro
 IPR027397; Catenin_binding_dom.
 IPR013558; CTNNB1-bd_N.
 IPR009071; HMG_box_dom.
 IPR024940; TCF/LEF. 
Pfam
 PF08347; CTNNB1_binding
 PF00505; HMG_box 
SMART
 SM00398; HMG 
PROSITE
 PS50118; HMG_BOX_2 
PRINTS