UniProt Accession

 K7EQB6_HUMAN; K7EQB6 

Genbank Protein ID

 AC004223; AC022903 

Genbank Nucleotide ID

  

Protein Name

 Leucine-rich repeats and immunoglobulin-like domains protein 3 

Protein Synonyms/Alias

  

Gene Name

 LIG3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
45	LLLPGVIKTVYNLND	acetylation	[1]
171	PNAYEAFKASRNLQD	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 185 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0000795; C:synaptonemal complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003910; F:DNA ligase (ATP) activity; IEA:InterPro.
 GO:0006310; P:DNA recombination; IEA:InterPro.
 GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:Compara.
 GO:0043504; P:mitochondrial DNA repair; IEA:Compara.
 GO:0045910; P:negative regulation of DNA recombination; IEA:Compara. 

Interpro

 IPR012308; DNA_ligase_ATP-dep_N. 

Pfam

 PF04675; DNA_ligase_A_N 

SMART

  

PROSITE

  

PRINTS