CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022994
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 230 
Protein Synonyms/Alias
 Zinc finger protein FDZF2 
Gene Name
 ZNF230 
Gene Synonyms/Alias
 FDZF2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
203SKCDMRGKEFSQSSCubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 8 76 KRAB.
 ZN_FING 168 190 C2H2-type 1.
 ZN_FING 196 218 C2H2-type 2.
 ZN_FING 224 246 C2H2-type 3.
 ZN_FING 252 274 C2H2-type 4.
 ZN_FING 280 302 C2H2-type 5.
 ZN_FING 308 330 C2H2-type 6.
 ZN_FING 336 358 C2H2-type 7.
 ZN_FING 364 386 C2H2-type 8.
 ZN_FING 392 414 C2H2-type 9.
 ZN_FING 420 442 C2H2-type 10; atypical.
 REGION 80 167 KRNB.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 474 AA 
Protein Sequence
MTTFKEAVTF KDVAVFFTEE ELGLLDPAQR KLYQDVMLEN FTNLLSVGHQ PFHPFHFLRE 60
EKFWMMETAT QREGNSGGKT IAEAGPHEDC PCQQIWEQTA SDLTQSQDSI INNSHFFEQG 120
DVPSQVEAGL SIIHTGQKPS QNGKCKQSFS DVAIFDPPQQ FHSGEKSHTC NECGKSFCYI 180
SALRIHQRVH LREKLSKCDM RGKEFSQSSC LQTRERVHTG EKPFKCEQCG KGFRCRAILQ 240
VHCKLHTGEK PYICEKCGRA FIHDFQLQKH QIIHTGEKPF KCEICGKSFC LRSSLNRHCM 300
VHTAEKLYKS EECGKGFTDS LDLHKHQIIH TGQKPYNCKE CGKSFRWSSY LLIHQRIHSG 360
EKPYRCEECG KGYISKSGLN LHQRVHTGER PYNCKECGKS FSRASSILNH KKLHCRKKPF 420
KCEDCGKRLV HRSFCKDQQG DHNGENSSKC EDCGKRYKRR LNLDIILSLF LNDM 474 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS