Tag | Content |
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CPLM ID | CPLM-016698 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dedicator of cytokinesis protein 8 |
Protein Synonyms/Alias | |
Gene Name | Dock8 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1357 | VSNQVLQKSRDVKAK | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP (By similarity). |
Sequence Annotation | DOMAIN 561 730 DHR-1. DOMAIN 1633 2067 DHR-2. MOD_RES 452 452 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2100 AA |
Protein Sequence | MATLPSAERR AFALKINRYS SSEIRKQFTL PPNLGQYHRH SISTSGFPSL QLPQLYEPVE 60 PVDFEGLVMT HLNSLDAELA QELGDLTDDD LHVAFTPKEC RTLQHSLPEE GVELDPHVRD 120 CVQTYIREWL IVNRKNQGSS EFCSFKKTGS RRDFQKTLQK QTFESETLEC SEPDTQTGPR 180 HPLNVLCDVS GKGPLTSCDF DLRSLQPDER LENLLQLVSA EDFEKEKEEA RKTNRPAELF 240 ALYPPVDEED AVEIRPVPEC PKEHLGNRIL VKVLTLKFEI EIEPLFASIA LYDVKERKKI 300 SENFHCDLNS DQFKGFLRAH TPSIDPSSQA RSAVFSVTYP SSDIYLVVKI EKVLQQGEIA 360 DCAEPYMIIK ESDGGKSKEK VEKLKLQAES FCQRLGKYRM PFAWAPISLA SFFNISTLER 420 ESTDVEPGVG RNSVGEKRSL SQSRRPSERT LSLEENGVGS NFKATTLATN IFFKQEGDRL 480 SDEDLFKFLA DYKRSSSLQR RVKSIPGSLR LEISPAPDVM NCCLTPEMLP VKPFPENRTR 540 PHKEILEFPI REVYVPHTVY RNLLYVYPQR LNFASKLASA RNITIKIQFM CGEDPSNAMP 600 VIFGKSSGPE FLQEVYTAIT YHNKSPDFYE EVKIKLPAKL TVNHHLLFTF YHISCQQKQG 660 ASGESLLGYS WLPILLNERL QTGSYCLPVA LEKLPPNYSI HSAEKVPLQN PPIKWAEGHK 720 GVFNIEVQAV SSVHTQDNHL EKFFTLCHSL ESQVSFPIRV LDQKITESTL EHELKLSIIC 780 LNSSRLEPLV LFLHLVLDKL FQLSVQPMVI AGQTANFSQF AFESVVAIAN SLHNSKDLRK 840 DQHGRNCLLA SYVHYVFRLP ELHRDTSKSG GPTTVVPDPR YHTYGRTSAA AVSSKLMQAR 900 VMSSSNPDLT GSHCAADEEV KNIMSSKIAD RNCSRMSYYC SGNSDAPGST AAPRPVSKKH 960 FHEELALQMV VSTGVVRETV FKYAWFFFEL LVKSMAQYVH NLDKRDSFRR TRFSDRFKDD 1020 ITTIVNVVTS EIAALLVKPQ KESEQAEKIN ISLAFFLYDL LSIMDRGFVF NLIKHYCSQL 1080 SAKLNILPTL ISMRLEFLRI LCSHEHYLNL NLLFMNTDTA PASPCPSISS QNSSSCSSFQ 1140 DQKIASMFDL TPEYRQQHFL TGLLFTELAV ALDAEGDGIS RVQRKAVSAI HSLLCSHDLD 1200 PRCRKPEVKV KIAALYLPLV GIILDALPQL YDFTDARSGR SRASGSYEEQ DVANGINQNV 1260 ALAIAGNHFN LKTSGAMLSS LPYKQYNMLN ADTTRHLMIC FLWIMKNADQ SLIRKWIADL 1320 PSMQLNRILD LLFICVSCFE YKGKQSSDKV SNQVLQKSRD VKAKLEEALL RGEGARGEMM 1380 RRRIPGTDRF PGINENLRWR KEQTQWRQAN EKLDKTKAEL DQEALISGNL ATEANLIILD 1440 MQENIIQASS ALDCKDSLLG GVLRVLVNSL SCDQSTTYLT HCFATLRALI AKFGDLLFEE 1500 EMEQCADLCQ RVLHHCSSSM DVTRSQACAT LYLLMRFSFG ATSNFARVKM QVTMALASLV 1560 GKAPDFNEEH LRRSLRTILA YSEEDTAMQT TPFPMQVEEL LCNLNSILYD TVKMREFQED 1620 PEMLMDLMYR IAKSYQASPD LRLTWLQNMA EKHTKKKCFT EAAMCLVHAA ALVAEYLSML 1680 EDHSYLPVGS VSFQNISSNV LEESAVSDDT LSPDEDGVCS GRYFTESGLV GLLEQAAELF 1740 STGGLYETVN EVYKLVIPIL EAHRDFRKLT STHDKLQKAF DNIINKDHKR MFGTYFRVGF 1800 YGSRFGDLDE QEFVYKEPAI TKLPEISHRL EGFYGQCFGA EFVEVIKDST PVDKTKLDPN 1860 KAYIQITFVE PYFDEYEMKD RVTYFEKNFN LRRFMYTTPF TLEGRPRGEL HEQHRRNTVL 1920 TTMHAFPYIK TRIRVSQKEE FVLTPIEVAI EDMKKKTLQL AVATHQEPPD AKMLQMVLQG 1980 SVGATVNQGP LEVAQVFLAE IPADPKLYRH HNKLRLCFKE FIMRCGEAVE KNRRLITAEQ 2040 REYQQELKKN YNKLRDSLRP MIERKIPELY KPIFRVDSQK RDSFHRSSFR KCETQLSQGS 2100 |
Gene Ontology | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |