| Tag | Content |
|---|
| CPLM ID | CPLM-014320 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alpha-1-syntrophin |
Protein Synonyms/Alias | 59 kDa dystrophin-associated protein A1 acidic component 1; Syntrophin-1 |
Gene Name | Snta1 |
Gene Synonyms/Alias | Snt1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 353 | LVHSGPSKGSVPYDA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5- bisphosphate. |
Sequence Annotation | DOMAIN 6 263 PH 1.
DOMAIN 81 164 PDZ.
DOMAIN 287 399 PH 2.
DOMAIN 447 503 SU.
REGION 481 503 Calmodulin-binding.
MOD_RES 183 183 Phosphoserine.
MOD_RES 187 187 Phosphoserine. |
Keyword | 3D-structure; Actin-binding; Calcium; Calmodulin-binding; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 503 AA |
Protein Sequence | MASGRRAPRT GLLELRCGAG SGAGGERWQR VLLSLAEDAL TVSPADGEPG PEPEPAQLNG 60
AAEPGAAPPQ LPEALLLQRR RVTVRKADAG GLGISIKGGR ENKMPILISK IFKGLAADQT 120
EALFVGDAIL SVNGEDLSSA THDEAVQALK KTGKEVVLEV KYMKEVSPYF KNSAGGTSVG 180
WDSPPASPLQ RQPSSPGPQP RNLSEAKHVS LKMAYVSRRC TPTDPEPRYL EICAADGQDA 240
VFLRAKDEAS ARSWAGAIQA QIGTFIPWVK DELQALLTAT GTAGSQDIKQ IGWLTEQLPS 300
GGTAPTLALL TEKELLFYCS LPQSREALSR PTRTAPLIAT SSAHRLVHSG PSKGSVPYDA 360
ELSFALRTGT RHGVDTHLFS VESPQELAAW TRQLVDGCHR AAEGIQEVST ACTWNGRPCS 420
LSVHIDKGFT LWAAEPGAAR AMLLRQPFEK LQMSSDDGTS LLFLDFGGAE GEIQLDLHSC 480
PKTMVFIIHS FLSAKVTRLG LLA 503 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-SubCell. GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0045211; C:postsynaptic membrane; IDA:MGI. GO:0043234; C:protein complex; ISO:MGI. GO:0042383; C:sarcolemma; IDA:MGI. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0007528; P:neuromuscular junction development; IMP:MGI. GO:0003117; P:regulation of vasoconstriction by circulating norepinephrine; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |