UniProt Accession

 BECN1_HUMAN; Q14457; O75595; Q9UNA8 

Genbank Protein ID

 AF077301; AF139131; BC010276; L38932 

Genbank Nucleotide ID

 AAC68653.1; AAD27650.1; AAH10276.1; AAB59573.1 

Protein Name

 Beclin-1 

Protein Synonyms/Alias

 Coiled-coil myosin-like BCL2-interacting protein; Protein GT197 

Gene Name

 BECN1 

Gene Synonyms/Alias

 GT197 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
26	QRCSQPLKLDTSFKI	ubiquitination	[1]
32	LKLDTSFKILDRVTI	ubiquitination	[2, 3]
206	EDVEKNRKIVAENLE	acetylation	[4]
206	EDVEKNRKIVAENLE	ubiquitination	[1]
214	IVAENLEKVQAEAER	ubiquitination	[1]
237	QREYSEFKRQQLELD	ubiquitination	[1]
248	LELDDELKSVENQMR	ubiquitination	[1]
263	YAQTQLDKLKKTNVF	ubiquitination	[1]
266	TQLDKLKKTNVFNAT	ubiquitination	[1]
324	LANKMGLKFQRYRLV	ubiquitination	[1]
402	RMDVEKGKIEDTGGS	ubiquitination	[1, 5]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. 

Sequence Annotation

 MOTIF 108 127 BH3.
 MOD_RES 119 119 Phosphothreonine; by DAPK1.  

Keyword

 3D-structure; Antiviral defense; Autophagy; Cell cycle; Cell division; Coiled coil; Complete proteome; Golgi apparatus; Host-virus interaction; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 450 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0000045; P:autophagic vacuole assembly; IEA:Compara.
 GO:0050435; P:beta-amyloid metabolic process; IEA:Compara.
 GO:0006968; P:cellular defense response; TAS:ProtInc.
 GO:0071275; P:cellular response to aluminum ion; IEA:Compara.
 GO:0000910; P:cytokinesis; IMP:UniProtKB.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0007040; P:lysosome organization; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0048666; P:neuron development; IEA:Compara.
 GO:0016239; P:positive regulation of macroautophagy; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0033197; P:response to vitamin E; IEA:Compara.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR007243; Beclin_fam. 

Pfam

 PF04111; APG6 

SMART

  

PROSITE

  

PRINTS