| Tag | Content |
|---|
| CPLM ID | CPLM-016199 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitochondrial sodium/hydrogen exchanger 9B2 |
Protein Synonyms/Alias | Mitochondrial Na(+)/H(+) exchanger NHA2; Na(+)/H(+) exchanger-like domain-containing protein 2; NHE domain-containing protein 2; Sodium/hydrogen exchanger-like domain-containing protein 2; Solute carrier family 9 subfamily B member 2 |
Gene Name | SLC9B2 |
Gene Synonyms/Alias | NHA2; NHEDC2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 38 | EETVMKLKGIDANEP | ubiquitination | [1] | | 53 | TEGSILLKSSEKKLQ | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity). |
Sequence Annotation | |
Keyword | Alternative splicing; Antiport; Complete proteome; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Polymorphism; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 537 AA |
Protein Sequence | MGDEDKRITY EDSEPSTGMN YTPSMHQEAQ EETVMKLKGI DANEPTEGSI LLKSSEKKLQ 60
ETPTEANHVQ RLRQMLACPP HGLLDRVITN VTIIVLLWAV VWSITGSECL PGGNLFGIII 120
LFYCAIIGGK LLGLIKLPTL PPLPSLLGML LAGFLIRNIP VINDNVQIKH KWSSSLRSIA 180
LSIILVRAGL GLDSKALKKL KGVCVRLSMG PCIVEACTSA LLAHYLLGLP WQWGFILGFV 240
LGAVSPAVVV PSMLLLQGGG YGVEKGVPTL LMAAGSFDDI LAITGFNTCL GIAFSTGSTV 300
FNVLRGVLEV VIGVATGSVL GFFIQYFPSR DQDKLVCKRT FLVLGLSVLA VFSSVHFGFP 360
GSGGLCTLVM AFLAGMGWTS EKAEVEKIIA VAWDIFQPLL FGLIGAEVSI ASLRPETVGS 420
ADSITGNFGT ERPKLLGPPS TQLRFHFFHI QLST 454 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005743; C:mitochondrial inner membrane; TAS:Reactome. GO:0015299; F:solute:hydrogen antiporter activity; IEA:InterPro. GO:0034220; P:ion transmembrane transport; TAS:Reactome. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |