Tag | Content |
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CPLM ID | CPLM-014558 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein SET |
Protein Synonyms/Alias | Liver regeneration-related protein LRRGR00002; Phosphatase 2A inhibitor I2PP2A; I-2PP2A; Template-activating factor I; TAF-I |
Gene Name | Set |
Gene Synonyms/Alias | Ab1-115 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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10 | APTAKASKKELNSNH | acetylation | [1] | 11 | PTAKASKKELNSNHD | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T- lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity). |
Sequence Annotation | REGION 31 77 Dimerization (By similarity). REGION 78 224 Earmuff domain (By similarity). MOD_RES 2 2 N,N,N-trimethylalanine (By similarity). MOD_RES 7 7 Phosphoserine (By similarity). MOD_RES 131 131 N6-acetyllysine (By similarity). MOD_RES 145 145 Phosphotyrosine (By similarity). MOD_RES 149 149 N6-acetyllysine (By similarity). MOD_RES 171 171 N6-acetyllysine (By similarity). CROSSLNK 153 153 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; DNA-binding; Endoplasmic reticulum; Isopeptide bond; Methylation; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 289 AA |
Protein Sequence | MSAPTAKASK KELNSNHDGA DETSEKEQQE AIEHIDEVQN EIDRLNEQAS EEILKVEQKY 60 NKLRQPFFQK RSELIAKIPN FWVTTFVNHP QVSALLGEED EEALHYLTRV EVTEFEDIKS 120 GYRIDFYFDE NPYFENKVLS KEFHLNESGD PSSKSTEIKW KSGKDLTKRS SQTQNKASRK 180 RQHEEPESFF TWFTDHSDAG ADELGEVIKD DIWPNPLQYY LVPDMDDEEG EAEDDDDDDE 240 EEEGLEDIDE EGDEDEGEED DDEDEGEEGE EDEGEDD 277 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell. GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB. GO:0043234; C:protein complex; IEA:Compara. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara. GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara. GO:0006334; P:nucleosome assembly; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |