CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018637
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Paralemmin-1 
Protein Synonyms/Alias
 Paralemmin 
Gene Name
 Palm 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
315EDEAETKKVLGLQDTubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Involved in plasma membrane dynamics and cell process formation. Necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner (By similarity). 
Sequence Annotation
 MOD_RES 116 116 Phosphoserine (By similarity).
 MOD_RES 124 124 Phosphoserine (By similarity).
 MOD_RES 141 141 Phosphothreonine (By similarity).
 MOD_RES 145 145 Phosphothreonine (By similarity).
 MOD_RES 152 152 Phosphoserine (By similarity).
 MOD_RES 157 157 Phosphoserine (By similarity).
 MOD_RES 161 161 Phosphoserine (By similarity).
 MOD_RES 345 345 Phosphoserine (By similarity).
 MOD_RES 363 363 Phosphothreonine (By similarity).
 MOD_RES 365 365 Phosphoserine (By similarity).
 MOD_RES 380 380 Cysteine methyl ester (Potential).
 LIPID 377 377 S-palmitoyl cysteine (Potential).
 LIPID 379 379 S-palmitoyl cysteine (Potential).
 LIPID 380 380 S-farnesyl cysteine (Potential).  
Keyword
 Cell membrane; Cell projection; Cell shape; Coiled coil; Complete proteome; Lipoprotein; Membrane; Methylation; Palmitate; Phosphoprotein; Prenylation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 383 AA 
Protein Sequence
MEVLATDTVS QQERLQAIAE KRRKQAEIES KRRQLEDDRR QLQYLKSKAL RERWLLEGTP 60
SSASEGDEDM RKQMQEDEQK ARSLEESITR LEKEIDVLEF GESAPAAPKE NSAAPSPIRP 120
HSTSPAKEEQ KSETMVNAQQ TPLGTPKENR KSTPVRSPGG STMMKAAMYS VEITVEKDKV 180
TGETRVLSST TLLPRDPLPQ GVKVYEDETK VVHAVDGLSE NGIQPLSSSE VDELIHKADE 240
VTLSEAGSTT GPAEPRGLAE DVTRTTPSRR EITGVEAQPG EATSGPPGIQ PGQEPPVTMV 300
FMGYQNVEDE AETKKVLGLQ DTIKAELVVI EDSVTPREPA PLNGSAAELP ATKEENQTGP 360
TTTPSDTQDL DMKKPRCRCC SVM 383 
Gene Ontology
 GO:0016327; C:apicolateral plasma membrane; IDA:UniProtKB.
 GO:0030424; C:axon; IDA:UniProtKB.
 GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0032590; C:dendrite membrane; IDA:UniProtKB.
 GO:0032591; C:dendritic spine membrane; IDA:UniProtKB.
 GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.
 GO:0009898; C:internal side of plasma membrane; TAS:RGD.
 GO:0071257; P:cellular response to electrical stimulus; IEA:Compara.
 GO:0007010; P:cytoskeleton organization; IEA:Compara.
 GO:0007194; P:negative regulation of adenylate cyclase activity; IEA:Compara.
 GO:0060160; P:negative regulation of dopamine receptor signaling pathway; IEA:Compara.
 GO:0060999; P:positive regulation of dendritic spine development; IEA:Compara.
 GO:0051491; P:positive regulation of filopodium assembly; IEA:Compara.
 GO:0072661; P:protein targeting to plasma membrane; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
 GO:0060074; P:synapse maturation; IEA:Compara. 
Interpro
 IPR004965; Paralemmin. 
Pfam
 PF03285; Paralemmin 
SMART
  
PROSITE
  
PRINTS