UniProt Accession

 NGDN_HUMAN; Q8NEJ9; A8K760; Q9Y400 

Genbank Protein ID

 AK291875; AL050003; CH471078; BC030817 

Genbank Nucleotide ID

 BAF84564.1; CAB43232.2; EAW66149.1; AAH30817.1 

Protein Name

 Neuroguidin 

Protein Synonyms/Alias

 EIF4E-binding protein 

Gene Name

 NGDN 

Gene Synonyms/Alias

 C14orf120 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	MAVTAQVKSLTQKVQ	ubiquitination	[1]
38	QVKSLTQKVQAGAYP	ubiquitination	[1, 2]
48	AGAYPTEKGLSFLEV	ubiquitination	[1]
112	KLKYQIDKLIKTAVT	ubiquitination	[2]
191	TEAEREKKRLERAKR	ubiquitination	[2]
210	SSVIRELKEQYSDAP	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity). 

Sequence Annotation

 REGION 41 174 Necessary for interaction with EIF4E (By
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 142 142 Phosphoserine.
 MOD_RES 143 143 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
 GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. 

Interpro

 IPR007146; Sas10/Utp3/C1D. 

Pfam

 PF04000; Sas10_Utp3 

SMART

  

PROSITE

  

PRINTS