| Tag | Content |
|---|
| CPLM ID | CPLM-005502 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rab proteins geranylgeranyltransferase component A 2 |
Protein Synonyms/Alias | Choroideremia-like protein; Rab escort protein 2; REP-2 |
Gene Name | CHML |
Gene Synonyms/Alias | REP2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 287 | RADVFNSKELTMVEK | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family. |
Sequence Annotation | |
Keyword | Complete proteome; GTPase activation; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 656 AA |
Protein Sequence | MADNLPTEFD VVIIGTGLPE SILAAACSRS GQRVLHIDSR SYYGGNWASF SFSGLLSWLK 60
EYQQNNDIGE ESTVVWQDLI HETEEAITLR KKDETIQHTE AFCYASQDME DNVEEIGALQ 120
KNPSLGVSNT FTEVLDSALP EESQLSYFNS DEMPAKHTQK SDTEISLEVT DVEESVEKEK 180
YCGDKTCMHT VSDKDGDKDE SKSTVEDKAD EPIRNRITYS QIVKEGRRFN IDLVSKLLYS 240
QGLLIDLLIK SDVSRYVEFK NVTRILAFRE GKVEQVPCSR ADVFNSKELT MVEKRMLMKF 300
LTFCLEYEQH PDEYQAFRQC SFSEYLKTKK LTPNLQHFVL HSIAMTSESS CTTIDGLNAT 360
KNFLQCLGRF GNTPFLFPLY GQGEIPQGFC RMCAVFGGIY CLRHKVQCFV VDKESGRCKA 420
IIDHFGQRIN AKYFIVEDSY LSEETCSNVQ YKQISRAVLI TDQSILKTDL DQQTSILIVP 480
PAEPGACAVR VTELCSSTMT CMKDTYLVHL TCSSSKTARE DLESVVKKLF TPYTETEINE 540
EELTKPRLLW ALYFNMRDSS GISRSSYNGL PSNVYVCSGP DCGLGNEHAV KQAETLFQEI 600
FPTEEFCPPP PNPEDIIFDG DDKQPEAPGT NNVVMAKLES SEESKNLESP EKHLQN 656 |
Gene Ontology | GO:0005968; C:Rab-protein geranylgeranyltransferase complex; IEA:InterPro. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0004663; F:Rab geranylgeranyltransferase activity; IEA:InterPro. GO:0006886; P:intracellular protein transport; IEA:InterPro. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0007601; P:visual perception; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |