CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017373
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Large neutral amino acids transporter small subunit 4 
Protein Synonyms/Alias
 L-type amino acid transporter 4; Solute carrier family 43 member 2 
Gene Name
 SLC43A2 
Gene Synonyms/Alias
 LAT4; PP7664 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
283GSSMRSAKEQVALQEubiquitination[1, 2]
402ASEEPEEKDANQGEKubiquitination[1]
558EDDKLFLKINGSSNQubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids. 
Sequence Annotation
 MOD_RES 274 274 Phosphoserine.
 MOD_RES 278 278 Phosphoserine.
 CARBOHYD 55 55 N-linked (GlcNAc...) (Potential).
 CARBOHYD 58 58 N-linked (GlcNAc...) (Potential).
 CARBOHYD 560 560 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Amino-acid transport; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 569 AA 
Protein Sequence
MAPTLATAHR RRWWMACTAV LENLLFSAVL LGWGSLLIML KSEGFYSYLC TEPENVTNGT 60
VGGTAEPGHE EVSWMNGWLS CQAQDEMLNL AFTVGSFLLS AITLPLGIVM DKYGPRKLRL 120
LGSACFAVSC LLIAYGASKP NALSVLIFIA LALNGFGGMC MTFTSLTLPN MFGDLRSTFI 180
ALMIGSYASS AVTFPGIKLI YDAGVSFIVV LVVWAGCSGL VFLNCFFNWP LEPFPGPEDM 240
DYSVKIKFSW LGFDHKITGK QFYKQVTTVG RRLSVGSSMR SAKEQVALQE GHKLCLSTVD 300
LEVKCQPDAA VAPSFMHSVF SPILLLSLVT MCVTQLRLIF YMGAMNNILK FLVSGDQKTV 360
GLYTSIFGVL QLLCLLTAPV IGYIMDWRLK ECEDASEEPE EKDANQGEKK KKKRDRQIQK 420
ITNAMRAFAF TNLLLVGFGV TCLIPNLPLQ ILSFILHTIV RGFIHSAVGG LYAAVYPSTQ 480
FGSLTGLQSL ISALFALLQQ PLFLAMMGPL QGDPLWVNVG LLLLSLLGFC LPLYLICYRR 540
QLERQLQQRQ EDDKLFLKIN GSSNQEAFV 569 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:Compara.
 GO:0006865; P:amino acid transport; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 
Interpro
 IPR027201; LAT4.
 IPR011701; MFS.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR027192; SLC43. 
Pfam
 PF07690; MFS_1 
SMART
  
PROSITE
 PS50850; MFS 
PRINTS