UniProt Accession

 SMAP2_HUMAN; Q8WU79; B2R7T1; B7Z5B5; B7Z8V2; D3DPV2; Q5QPL2; Q96C93; Q9NST2; Q9UJL8 

Genbank Protein ID

 AL133206; AL137764; AK298702; AK303975; AK313105; AK316218; AL031985; AL031985; AL031985; CH471059; CH471059; CH471059; BC014512; BC021133 

Genbank Nucleotide ID

 CAB61580.1; CAB70912.1; BAH12851.1; BAH14088.1; BAG35928.1; BAH14589.1; CAI19853.1; CAI19854.1; CAI19855.1; EAX07220.1; EAX07222.1; EAX07221.1; AAH14512.1; AAH21133.1 

Protein Name

 Stromal membrane-associated protein 2 

Protein Synonyms/Alias

 Stromal membrane-associated protein 1-like 

Gene Name

 SMAP2 

Gene Synonyms/Alias

 SMAP1L 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
88	MQEMGNGKANRLYEA	ubiquitination	[1]
151	GSEPVPEKKLEPVVF	acetylation	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). 

Sequence Annotation

 DOMAIN 13 137 Arf-GAP.
 ZN_FING 28 51 C4-type.
 REGION 163 232 Interaction with clathrin heavy chains
 REGION 340 429 Interaction with PICALM (By similarity).
 MOD_RES 219 219 Phosphoserine.
 MOD_RES 225 225 Phosphoserine.
 MOD_RES 240 240 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; GTPase activation; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 429 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro. 

Interpro

 IPR001164; ArfGAP. 

Pfam

 PF01412; ArfGap 

SMART

 SM00105; ArfGap 

PROSITE

 PS50115; ARFGAP 

PRINTS

 PR00405; REVINTRACTNG.