UniProt Accession

 HIRA_MOUSE; Q61666; O08845; Q3TFY0; Q3UX35; Q62365; Q7TMW4 

Genbank Protein ID

 X92590; X99712; X75295; AK135928; AK168963; BC052856 

Genbank Nucleotide ID

 CAA63334.1; CAA68049.1; CAA53043.1; BAE22728.1; BAE40768.1; AAH52856.1 

Protein Name

 Protein HIRA 

Protein Synonyms/Alias

 TUP1-like enhancer of split protein 1 

Gene Name

 Hira 

Gene Synonyms/Alias

 Tuple1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
114	TVFGSSGKLANVEQW	acetylation	[1]
599	LKEQNLVKELRSREL	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. 

Sequence Annotation

 REPEAT 11 53 WD 1.
 REPEAT 68 107 WD 2.
 REPEAT 129 168 WD 3.
 REPEAT 172 211 WD 4.
 REPEAT 220 263 WD 5.
 REPEAT 266 322 WD 6.
 REPEAT 326 367 WD 7.
 REPEAT 770 807 WD 8.
 REGION 421 727 Interaction with CCNA1 (By similarity).
 REGION 421 479 Interaction with ASF1A (By similarity).
 REGION 439 475 Required for repression of histone gene
 REGION 593 737 Interaction with PAX3.
 REGION 594 824 Interaction with histone H2B (By
 REGION 736 1015 Interaction with histone H4 (By
 REGION 738 826 Interaction with PAX3.
 MOD_RES 548 548 Phosphoserine (By similarity).
 MOD_RES 554 554 Phosphothreonine.
 MOD_RES 556 556 Phosphoserine (By similarity).
 MOD_RES 575 575 Phosphothreonine (By similarity).
 MOD_RES 583 583 Phosphoserine (By similarity).
 MOD_RES 608 608 Phosphoserine (By similarity).
 MOD_RES 609 609 Phosphoserine (By similarity).
 MOD_RES 610 610 Phosphoserine (By similarity).
 MOD_RES 612 612 Phosphoserine (By similarity).
 MOD_RES 659 659 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1015 AA 

Protein Sequence

Gene Ontology

 GO:0000790; C:nuclear chromatin; IDA:MGI.
 GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0007369; P:gastrulation; IMP:MGI.
 GO:0042692; P:muscle cell differentiation; IGI:MGI.
 GO:0001649; P:osteoblast differentiation; IGI:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011494; Hira.
 IPR019015; HIRA_B_motif.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF07569; Hira
 PF09453; HIRA_B
 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS