| Tag | Content |
|---|
| CPLM ID | CPLM-013607 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho guanine nucleotide exchange factor 15 |
Protein Synonyms/Alias | Ephexin-5; E5 |
Gene Name | Arhgef15 |
Gene Synonyms/Alias | Kiaa0915 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 594 | SRQENAQKALGAVSK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. |
Sequence Annotation | DOMAIN 425 609 DH.
MOD_RES 83 83 Phosphothreonine.
MOD_RES 84 84 Phosphoserine.
MOD_RES 361 361 Phosphotyrosine; by EPHB2 (Probable). |
Keyword | Alternative splicing; Cell projection; Complete proteome; GTPase activation; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 849 AA |
Protein Sequence | MSAQSLPAAT PPTLKPPRII RPRPPSRHRA PHSPGPLHNG SSPKALPQIS NDASASVCTS 60
IFWEPPTASL KPPALLPPSV SRTSLDSQTS PDSPSSTPSP SPVSRRSISP EPAPCSPVPP 120
PKPSGSSRTP LPSGPTPLQD GSASAPGTVR RLAGKFEWGA EGKAQSSDSL ERCSQGSTEV 180
NGEKETPEAA LSGNGSQENG TPDAALACPP CCPCVCHVAK PGLELRWVPV GSSEDILRIP 240
CRASPLRASR SRINPPVISH PPVVLTSYRS TAERKLLPPL KPPKPTKVRQ DISTSEELPQ 300
PDLKLPSEDG IQTATKAWEG DRPEGAPLNA PPVALEGREE EGLDGLKGLQ WELPLQDEPL 360
YQTYRAAVLS EELWGVGEDG GPSPANPGEA PTFSRLPGPR NTLWQELPAV RGSGLLESLS 420
PQERRMQESL FEVVTSEASY LRSLRLLTDT FVLSQALRDT LTPRDHHTLF SNVQRVQSVS 480
ERFLGTLLSR VRSSPHITDL CDVVHAHAVG PFFVYVDYVR NQQYQEETYS RLMDTNVRFS 540
AELRRLQSLP KCERLPLPSF LLLPFQRITR LRMLLQNILS QTEEGSSRQE NAQKALGAVS 600
KIIERCSAEV GRMKQTEELI RLTQRLRFHK VKALPLVSWS RRLELQGELT ELGCRRGGVL 660
FTSRPRFTPL CLLLFSDLLL ITQPKSGQRL QVLDYAHRSL VQAQQVPDPS GPPTFRLSLL 720
SNHQGRPTHR LLQAASLSDM QRWLGAFPTP GPLPCSPDTI YEDCECSQEL CSEPSTPSKT 780
EGQSLESKAP RKHLHKNPEG WLKGLPGAFP AQLVCEVTGE HERRKHLRQH QKLLEAVGPS 840
SGTPDTPQP 849 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0030425; C:dendrite; IDA:UniProtKB. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:UniProtKB. GO:2000297; P:negative regulation of synapse maturation; IMP:UniProtKB. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0051496; P:positive regulation of stress fiber assembly; ISS:UniProtKB. GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. GO:0061299; P:retina vasculature morphogenesis in camera-type eye; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |