| Tag | Content |
|---|
| CPLM ID | CPLM-002391 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Thymidylate synthase |
Protein Synonyms/Alias | TS; TSase; Cell division cycle protein 21; Constitutive RNR3 transcription protein 9 |
Gene Name | CDC21 |
Gene Synonyms/Alias | CRT9; TMP1; YOR074C; YOR29-25 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 102 | GSREYLDKMGFKDRK | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Thymidylate synthase required for de novo biosynthesis of pyrimidine deoxyribonucleotides. Required for both nuclear and mitochondrial DNA synthesis. |
Sequence Annotation | ACT_SITE 177 177 By similarity. |
Keyword | Complete proteome; Direct protein sequencing; Methyltransferase; Nucleotide biosynthesis; Nucleus; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 304 AA |
Protein Sequence | MTMDGKNKEE EQYLDLCKRI IDEGEFRPDR TGTGTLSLFA PPQLRFSLRD DTFPLLTTKK 60
VFTRGIILEL LWFLAGDTDA NLLSEQGVKI WDGNGSREYL DKMGFKDRKV GDLGPVYGFQ 120
WRHFGAKYKT CDDDYTGQGI DQLKQVIHKL KTNPYDRRII MSAWNPADFD KMALPPCHIF 180
SQFYVSFPKE GEGSGKPRLS CLLYQRSCDM GLGVPFNIAS YALLTRMIAK VVDMEPGEFI 240
HTLGDAHVYK DHIDALKEQI TRNPRPFPKL KIKRDVKDID DFKLTDFEIE DYNPHPRIQM 300
KMSV 304 |
Gene Ontology | GO:0005634; C:nucleus; IDA:SGD. GO:0004799; F:thymidylate synthase activity; IDA:SGD. GO:0006231; P:dTMP biosynthetic process; IMP:SGD. GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |