UniProt Accession

 CH3L2_HUMAN; Q15782; A6NNY3; B4DPR7; Q15749; Q15783; Q5VUV7; Q96F97 

Genbank Protein ID

 U58515; U58514; U49835; BT006767; AK298466; AL355816; AL513202; CH471122; BC011460 

Genbank Nucleotide ID

 AAB04534.1; AAB04533.1; AAC50597.1; AAP35413.1; BAG60679.1; EAW56481.1; AAH11460.1 

Protein Name

 Chitinase-3-like protein 2 

Protein Synonyms/Alias

 Chondrocyte protein 39; YKL-39 

Gene Name

 CHI3L2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
89	YQTINSLKTKNPKLK	ubiquitination	[1]
199	DNSYQVEKLAKDLDF	ubiquitination	[1, 2]
202	YQVEKLAKDLDFINL	ubiquitination	[1]
329	QQVPYAVKGNQWVGY	ubiquitination	[1, 2]
340	WVGYDDVKSMETKVQ	ubiquitination	[1, 2]
345	DVKSMETKVQFLKNL	ubiquitination	[1, 2]
384	YPLVQAVKRSLGSL*	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. 

Sequence Annotation

 BINDING 104 104 Chitooligosaccharide.
 BINDING 146 146 Chitooligosaccharide.
 BINDING 213 213 Chitooligosaccharide.
 BINDING 360 360 Chitooligosaccharide.
 CARBOHYD 35 35 N-linked (GlcNAc...) (Potential).
 DISULFID 31 56 By similarity.  

Keyword

 3D-structure; Alternative splicing; Chitin-binding; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Lectin; Polymorphism; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 390 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; TAS:ProtInc.
 GO:0008061; F:chitin binding; IDA:UniProtKB.
 GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
 GO:0006032; P:chitin catabolic process; IEA:InterPro. 

Interpro

 IPR011583; Chitinase_II.
 IPR001223; Glyco_hydro18cat.
 IPR013781; Glyco_hydro_catalytic_dom.
 IPR017853; Glycoside_hydrolase_SF. 

Pfam

 PF00704; Glyco_hydro_18 

SMART

 SM00636; Glyco_18 

PROSITE

 PS01095; CHITINASE_18 

PRINTS