UniProt Accession

 FCF2_YEAST; Q12035; D6VY53 

Genbank Protein ID

 X94607; Z73223; BK006945 

Genbank Nucleotide ID

 CAA64298.1; CAA97581.1; DAA09369.1 

Protein Name

 rRNA-processing protein FCF2 

Protein Synonyms/Alias

 FAF1 copurifying factor 2 

Gene Name

 FCF2 

Gene Synonyms/Alias

 YLR051C; L2128 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
156	IGTIIEDKSEFYSSR	ubiquitination	[1]
197	KYNEIQEKSTSGRKA	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites. 

Sequence Annotation

  

Keyword

 Complete proteome; Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. 

Interpro

 IPR014810; Fcf2. 

Pfam

 PF08698; Fcf2 

SMART

  

PROSITE

  

PRINTS