UniProt Accession

 YHAV_ECOLI; P64594; P42901; Q2M979 

Genbank Protein ID

 U18997; U00096; AP009048 

Genbank Nucleotide ID

 AAA57933.1; AAC76164.1; BAE77177.1 

Protein Name

 Toxin YhaV 

Protein Synonyms/Alias

 Ribonuclease YhaV 

Gene Name

 yhaV 

Gene Synonyms/Alias

 b3130; JW3099 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
87	NKDWSRVKFGAGRYR	acetylation	[1]
132	DAYTVFSKMLKRGHP	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Toxic component of a toxin-antitoxin (TA) module. Has RNase activity in vitro. Overexpression leads to growth arrest after 30 minutes; these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression. 

Sequence Annotation

  

Keyword

 Complete proteome; Endonuclease; Hydrolase; Nuclease; Reference proteome; Repressor; Toxin; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 154 AA 

Protein Sequence

Gene Ontology

 GO:0004521; F:endoribonuclease activity; IDA:EcoCyc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc.
 GO:0030308; P:negative regulation of cell growth; IMP:EcoCyc.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR021679; Toxin_endonuclease_YhaV. 

Pfam

 PF11663; Toxin_YhaV 

SMART

  

PROSITE

  

PRINTS