| Tag | Content |
|---|
| CPLM ID | CPLM-005464 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcriptional regulatory protein ZraR |
Protein Synonyms/Alias | |
Gene Name | zraR |
Gene Synonyms/Alias | hydG; STM4174; STMF1.27 |
Created Date | July 27, 2013 |
Organism | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
NCBI Taxa ID | 99287 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 416 | VILAALEKTGGNKTE | acetylation | [1] | | 421 | LEKTGGNKTEAARQL | acetylation | [1] | | 433 | RQLGITRKTLLAKLS | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon (By similarity). |
Sequence Annotation | DOMAIN 7 121 Response regulatory.
DOMAIN 141 370 Sigma-54 factor interaction.
NP_BIND 169 176 ATP (Potential).
NP_BIND 232 241 ATP (Potential).
DNA_BIND 421 440 H-T-H motif (By similarity).
MOD_RES 56 56 4-aspartylphosphate (By similarity). |
Keyword | 3D-structure; Activator; ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 441 AA |
Protein Sequence | MIRGKIDILV VDDDVSHCTI LQALLRGWGY NVALAYSGHD ALAQVREKVF DLVLCDVRMA 60
EMDGIATLKE IKALNPAIPI LIMTAFSSVE TAVEALKAGA LDYLIKPLDF DRLQETLEKA 120
LAHTRETGAE LPSASAAQFG MIGSSPAMQH LLNEIAMVAP SDATVLIHGD SGTGKELVAR 180
ALHACSARSD RPLVTLNCAA LNESLLESEL FGHEKGAFTG ADKRREGRFV EADGGTLFLD 240
EIGDISPLMQ VRLLRAIQER EVQRVGSNQT ISVDVRLIAA THRDLAEEVS AGRFRQDLYY 300
RLNVVAIEMP SLRQRREDIP LLADHFLRRF AERNRKVVKG FTPQAMDLLI HYDWPGNIRE 360
LENAIERAVV LLTGEYISER ELPLAIAATP IKTEYSGEIQ PLVDVEKEVI LAALEKTGGN 420
KTEAARQLGI TRKTLLAKLS R 441 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0035556; P:intracellular signal transduction; IEA:GOC. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
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PROSITE | |
PRINTS | |