UniProt Accession

 CSN3_MOUSE; O88543 

Genbank Protein ID

 AF071313; BC068179 

Genbank Nucleotide ID

 AAC33900.1; AAH68179.1 

Protein Name

 COP9 signalosome complex subunit 3 

Protein Synonyms/Alias

 SGN3; Signalosome subunit 3; JAB1-containing signalosome subunit 3 

Gene Name

 Cops3 

Gene Synonyms/Alias

 Csn3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
125	LRGIGILKQAIDKMQ	acetylation	[1]
125	LRGIGILKQAIDKMQ	ubiquitination	[2]
171	VDMMDICKENGAYDA	ubiquitination	[2]
281	ELRNLVSKHSETFTR	ubiquitination	[2]
312	KNIQRLTKTFLTLSL	ubiquitination	[2]
366	SFHDNPEKYNNPAML	ubiquitination	[2]
391	IELDERLKAMDQEIT	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo. 

Sequence Annotation

 DOMAIN 195 362 PCI.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 410 410 Phosphoserine (By similarity).
 MOD_RES 421 421 Phosphoserine (By similarity).
 MOD_RES 423 423 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Signalosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008180; C:signalosome; IDA:MGI.
 GO:0010388; P:cullin deneddylation; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IMP:MGI. 

Interpro

 IPR000717; PCI_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF01399; PCI 

SMART

 SM00088; PINT 

PROSITE

  

PRINTS