CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001184
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PERQ amino acid-rich with GYF domain-containing protein 1 
Protein Synonyms/Alias
 GRB10-interacting GYF protein 1 
Gene Name
 GIGYF1 
Gene Synonyms/Alias
 CDS2; PERQ1; PP3360 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
35SPAMPKYKLADYRYGubiquitination[1]
787EGERQLHKQPPPREPubiquitination[1]
846GLWEDTPKSGGSLVRubiquitination[1]
952LGDTLEAKEFAKQFLubiquitination[1]
956LEAKEFAKQFLERRAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). 
Sequence Annotation
 DOMAIN 474 522 GYF.
 MOD_RES 24 24 Phosphoserine.
 MOD_RES 28 28 Phosphoserine.
 MOD_RES 137 137 Phosphoserine.
 MOD_RES 638 638 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1035 AA 
Protein Sequence
MAAETLNFGP EWLRALSGGG SVASPPPSPA MPKYKLADYR YGREEMLALY VKENKVPEEL 60
QDKEFAAVLQ DEPLQPLALE PLTEEEQRNF SLSVNSVAVL RLMGKGAGPP LAGTSRGRGS 120
TRSRGRGRGD SCFYQRSIEE GDGAFGRSPR EIQRSQSWDD RGERRFEKSA RRDGARCGFE 180
EGGAGPRKEH ARSDSENWRS LREEQEEEEE GSWRLGAGPR RDGDRWRSAS PDGGPRSAGW 240
REHGERRRKF EFDLRGDRGG CGEEEGRGGG GSSHLRRCRA PEGFEEDKDG LPEWCLDDED 300
EEMGTFDASG AFLPLKKGPK EPIPEEQELD FQGLEEEEEP SEGLEEEGPE AGGKELTPLP 360
PQEEKSSSPS PLPTLGPLWG TNGDGDETAE KEPPAAEDDI RGIQLSPGVG SSAGPPGDLE 420
DDEGLKHLQQ EAEKLVASLQ DSSLEEEQFT AAMQTQGLRH SAAATALPLS HGAARKWFYK 480
DPQGEIQGPF TTQEMAEWFQ AGYFSMSLLV KRGCDEGFQP LGEVIKMWGR VPFAPGPSPP 540
PLLGNMDQER LKKQQELAAA ALYQQLQHQQ FLQLVSSRQL PQCALREKAA LGDLTPPPPP 600
PPQQQQQQLT AFLQQLQALK PPRGGDQNLL PTMSRSLSVP DSGRLWDVHT SASSQSGGEA 660
SLWDIPINSS TQGPILEQLQ LQHKFQERRE VELRAKREEE ERKRREEKRR QQQQEEQKRR 720
QEEEELFRRK HVRQQELLLK LLQQQQAVPV PPAPSSPPPL WAGLAKQGLS MKTLLELQLE 780
GERQLHKQPP PREPARAQAP NHRVQLGGLG TAPLNQWVSE AGPLWGGPDK SGGGSSGLGL 840
WEDTPKSGGS LVRGLGLKNS RSSPSLSDSY SHLSGRPIRK KTEEEEKLLK LLQGIPRPQD 900
GFTQWCEQML HTLSATGSLD VPMAVAILKE VESPYDVHDY IRSCLGDTLE AKEFAKQFLE 960
RRAKQKASQQ RQQQQEAWLS SASLQTAFQA NHSTKLGPGE GSKAKRRALM LHSDPSILGY 1020
SLHGSSGEIE SVDDY 1035 
Gene Ontology
 GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Compara. 
Interpro
 IPR003169; GYF. 
Pfam
 PF02213; GYF 
SMART
 SM00444; GYF 
PROSITE
 PS50829; GYF 
PRINTS