UniProt Accession

 HNRPD_HUMAN; Q14103; A8K9J2; P07029; Q01858; Q14100; Q14101; Q14102; Q4W5A1; Q9UCE8; Q9UCE9 

Genbank Protein ID

 D55671; D55672; D55673; D55674; AF026126; AF026126; AF026126; AK292707; AC124016; CH471057; BC002401; BC023977; BC026015; X03910; AF039575; M94630 

Genbank Nucleotide ID

 BAA09522.1; BAA09523.1; BAA09524.1; BAA09525.1; AAC23474.1; AAC23475.1; AAC23476.1; BAF85396.1; AAY40913.1; EAX05874.1; AAH02401.1; AAH23977.1; AAH26015.1; CAA27544.1; AAB96683.1; AAA35781.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein D0 

Protein Synonyms/Alias

 hnRNP D0; AU-rich element RNA-binding protein 1 

Gene Name

 HNRNPD 

Gene Synonyms/Alias

 AUF1; HNRPD 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
273	DQQSGYGKVSRRGGH	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'- TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. 

Sequence Annotation

 DOMAIN 97 179 RRM 1.
 DOMAIN 182 261 RRM 2.
 MOD_RES 71 71 Phosphoserine.
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 82 82 Phosphoserine.
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 119 119 N6-methyllysine.
 MOD_RES 165 165 N6-acetyllysine.
 MOD_RES 190 190 Phosphoserine.
 MOD_RES 193 193 Phosphothreonine.
 MOD_RES 251 251 N6-acetyllysine.
 MOD_RES 345 345 Dimethylated arginine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 355 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IDA:UniProtKB.
 GO:0042162; F:telomeric DNA binding; IDA:UniProtKB.
 GO:0000398; P:mRNA splicing, via spliceosome; TAS:Reactome.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0043488; P:regulation of mRNA stability; IEA:Compara.
 GO:0006401; P:RNA catabolic process; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012956; CARG-binding_factor_N.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF08143; CBFNT
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS