CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018371
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Intraflagellar transport protein 81 homolog 
Protein Synonyms/Alias
 Carnitine deficiency-associated protein expressed in ventricle 1; CDV-1 
Gene Name
 IFT81 
Gene Synonyms/Alias
 CDV1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14FIMDSLNKEPFRKNYubiquitination[1]
75LLGILKYKPSGNATDubiquitination[1]
156EAFKTLHKEYEQLKIubiquitination[1]
182ISAMEEEKDQLIKRVubiquitination[1]
187EEKDQLIKRVEHLKKubiquitination[1]
216ARQLRVEKEREEYLAubiquitination[1]
226EEYLAQQKQEQKNQLubiquitination[1, 2]
230AQQKQEQKNQLFHAVubiquitination[1]
248QRVQNQLKSMRQAAAubiquitination[1]
264AKPESLMKRLEEEIKubiquitination[1]
290KELENKKKELHFLQKacetylation[3]
330INQLIEKKMMRNEPIubiquitination[1]
340RNEPIEGKLSLYRQQubiquitination[1]
393FDGTEVLKGDEFKRYubiquitination[1]
398VLKGDEFKRYVNKLRubiquitination[1]
414KSTVFKKKHQIIAELubiquitination[1]
436QRTEELLKQRHENIQubiquitination[1]
453LQTMEEKKGISGYSYubiquitination[1]
472LERVSALKSEVDEMKubiquitination[1]
479KSEVDEMKGRTLDDMubiquitination[1]
492DMSEMVKKLYSLVSEubiquitination[1]
500LYSLVSEKKSALASVubiquitination[1]
501YSLVSEKKSALASVIubiquitination[1]
509SALASVIKELRQLRQubiquitination[1]
529TQECDEKKSQYDSCAubiquitination[1]
545GLESNRSKLEQEVRRubiquitination[1]
596ISSDQQEKRKAIREQubiquitination[1]
598SDQQEKRKAIREQYTubiquitination[1]
606AIREQYTKNTAEQENubiquitination[1]
650EQLMECKKQCFLKQQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Isoform CDV-1 may be involved in cardiac hypertrophy caused by carnitine deficiency (By similarity). 
Sequence Annotation
 MOD_RES 61 61 Phosphothreonine.  
Keyword
 Alternative initiation; Alternative splicing; Coiled coil; Complete proteome; Developmental protein; Differentiation; Phosphoprotein; Reference proteome; Spermatogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 676 AA 
Protein Sequence
MSDQIKFIMD SLNKEPFRKN YNLITFDSLE PMQLLQVLSD VLAEIDPKQL VDIREEMPEQ 60
TAKRMLSLLG ILKYKPSGNA TDMSTFRQGL VIGSKPVIYP VLHWLLQRTN ELKKRAYLAR 120
FLIKLEVPSE FLQDETVADT NKQYEELMEA FKTLHKEYEQ LKISGFSTAE IRKDISAMEE 180
EKDQLIKRVE HLKKRVETAQ NHQWMLKIAR QLRVEKEREE YLAQQKQEQK NQLFHAVQRL 240
QRVQNQLKSM RQAAADAKPE SLMKRLEEEI KFNLYMVTEK FPKELENKKK ELHFLQKVVS 300
EPAMGHSDLL ELESKINEIN TEINQLIEKK MMRNEPIEGK LSLYRQQASI ISRKKEAKAE 360
ELQEAKEKLA SLEREASVKR NQTREFDGTE VLKGDEFKRY VNKLRSKSTV FKKKHQIIAE 420
LKAEFGLLQR TEELLKQRHE NIQQQLQTME EKKGISGYSY TQEELERVSA LKSEVDEMKG 480
RTLDDMSEMV KKLYSLVSEK KSALASVIKE LRQLRQKYQE LTQECDEKKS QYDSCAAGLE 540
SNRSKLEQEV RRLREECLQE ESRYHYTNCM IKNLEVQLRR ATDEMKAYIS SDQQEKRKAI 600
REQYTKNTAE QENLGKKLRE KQKVIRESHG PNMKQAKMWR DLEQLMECKK QCFLKQQSQT 660
SIGQVIQEGG EDRLIL 676 
Gene Ontology
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0030992; C:intraflagellar transport particle B; ISS:BHF-UCL.
 GO:0031514; C:motile cilium; ISS:BHF-UCL.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; ISS:UniProtKB. 
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