CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026298
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein argonaute-1 
Protein Synonyms/Alias
  
Gene Name
 AGO1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
258LQVGQEQKHTYLPLEubiquitination[1]
289NQTSTMIKATARSAPubiquitination[1, 2, 3]
307EEISRLMKNASYNLDubiquitination[1]
383IACFAPQKQCREEVLubiquitination[1]
402DQLRKISKDAGMPIQubiquitination[1]
416QGQPCFCKYAQGADSubiquitination[1, 4]
456TPVYAEVKRVGDTLLubiquitination[2]
578ELLIQFYKSTRFKPTubiquitination[1]
643TRLFCADKNERIGKSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 782 AA 
Protein Sequence
MVQHFKPQIF GDRKPVYDGK KNIYTVTALP IGNERVDFEV TIPGEGKDRI FKVSIKWLAI 60
VSWRMLHEAL VSGQIPVPLE SVQALDVAMR HLASMRYTPV GRSFFSPPEG YYHPLGGGRE 120
VWFGFHQSVR PAMWKMMLNI DVSATAFYKA QPVIEFMCEV LDIRNIDEQP KPLTDSQRVR 180
FTKEIKGLKV EVTHCGQMKR KYRVCNVTRR PASHQTFPLQ LESGQTVECT VAQYFKQKYN 240
LQLKYPHLPC LQVGQEQKHT YLPLEVCNIV AGQRCIKKLT DNQTSTMIKA TARSAPDRQE 300
EISRLMKNAS YNLDPYIQEF GIKVKDDMTE VTGRVLPAPI LQYGGRNRAI ATPNQGVWDM 360
RGKQFYNGIE IKVWAIACFA PQKQCREEVL KNFTDQLRKI SKDAGMPIQG QPCFCKYAQG 420
ADSVEPMFRH LKNTYSGLQL IIVILPGKTP VYAEVKRVGD TLLGMATQCV QVKNVVKTSP 480
QTLSNLCLKI NVKLGGINNI LVPHQRSAVF QQPVIFLGAD VTHPPAGDGK KPSITAVVGS 540
MDAHPSRYCA TVRVQRPRQE IIEDLSYMVR ELLIQFYKST RFKPTRIIFY RDGVPEGQLP 600
QILHYELLAI RDACIKLEKD YQPGITYIVV QKRHHTRLFC ADKNERIGKS GNIPAGTTVD 660
TNITHPFEFD FYLCSHAGIQ GTSRPSHYYV LWDDNRFTAD ELQILTYQLC HTYVRCTRSV 720
SIPAPAYYAR LVAFRARYHL VDKEHDSGEG SHISGQSNGR DPQALAKAVQ VHQDTLRTMY 780
FA 782 
Gene Ontology
 GO:0000932; C:cytoplasmic mRNA processing body; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:Compara. 
Interpro
 IPR014811; DUF1785.
 IPR003100; PAZ.
 IPR003165; Piwi.
 IPR012337; RNaseH-like_dom. 
Pfam
 PF08699; DUF1785
 PF02170; PAZ
 PF02171; Piwi 
SMART
 SM00949; PAZ
 SM00950; Piwi 
PROSITE
 PS50821; PAZ
 PS50822; PIWI 
PRINTS