CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002987
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable inorganic polyphosphate/ATP-NAD kinase 
Protein Synonyms/Alias
 Poly(P)/ATP NAD kinase 
Gene Name
 ppnK 
Gene Synonyms/Alias
 yfjB; yfjE; b2615; JW2596 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
50IAHELQLKNVKTGTLacetylation[1]
89TLARYDIKVIGINRGacetylation[1]
125EGHYISEKRFLLEAQacetylation[1]
273HLNLIHPKDYSYFNTacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Kinase; NAD; NADP; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 292 AA 
Protein Sequence
MNNHFKCIGI VGHPRHPTAL TTHEMLYRWL CTKGYEVIVE QQIAHELQLK NVKTGTLAEI 60
GQLADLAVVV GGDGNMLGAA RTLARYDIKV IGINRGNLGF LTDLDPDNAQ QQLADVLEGH 120
YISEKRFLLE AQVCQQDCQK RISTAINEVV LHPGKVAHMI EFEVYIDEIF AFSQRSDGLI 180
ISTPTGSTAY SLSAGGPILT PSLDAITLVP MFPHTLSARP LVINSSSTIR LRFSHRRNDL 240
EISCDSQIAL PIQEGEDVLI RRCDYHLNLI HPKDYSYFNT LSTKLGWSKK LF 292 
Gene Ontology
 GO:0005829; C:cytosol; IDA:EcoCyc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:HAMAP.
 GO:0003951; F:NAD+ kinase activity; IDA:EcoCyc.
 GO:0019674; P:NAD metabolic process; IEA:InterPro.
 GO:0006741; P:NADP biosynthetic process; IDA:EcoCyc. 
Interpro
 IPR017438; ATP-NAD_kinase_dom_1.
 IPR016064; ATP-NAD_kinase_PpnK-typ.
 IPR017437; ATP-NAD_kinase_PpnK-typ_all-b.
 IPR002504; PolyP/ATP_NADK_prd. 
Pfam
 PF01513; NAD_kinase 
SMART
  
PROSITE
  
PRINTS