| Tag | Content |
|---|
| CPLM ID | CPLM-023590 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ectonucleoside triphosphate diphosphohydrolase 4 |
Protein Synonyms/Alias | NTPDase 4; Lysosomal apyrase-like protein of 70 kDa; Uridine-diphosphatase; UDPase |
Gene Name | ENTPD4 |
Gene Synonyms/Alias | KIAA0392; LALP70; LYSAL1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 464 | AKDYCATKWSILRER | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP. |
Sequence Annotation | ACT_SITE 222 222 Proton acceptor (By similarity).
CARBOHYD 404 404 N-linked (GlcNAc...) (Potential).
CARBOHYD 407 407 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Calcium; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Golgi apparatus; Hydrolase; Magnesium; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 616 AA |
Protein Sequence | MGRIGISCLF PASWHFSISP VGCPRILNTN LRQIMVISVL AAAVSLLYFS VVIIRNKYGR 60
LTRDKKFQRY LARVTDIEAT DTNNPNVNYG IVVDCGSSGS RVFVYCWPRH NGNPHDLLDI 120
RQMRDKNRKP VVMKIKPGIS EFATSPEKVS DYISPLLNFA AEHVPRAKHK ETPLYILCTA 180
GMRILPESQQ KAILEDLLTD IPVHFDFLFS DSHAEVISGK QEGVYAWIGI NFVLGRFEHI 240
EDDDEAVVEV NIPGSESSEA IVRKRTAGIL DMGGVSTQIA YEVPKTVSFA SSQQEEVAKN 300
LLAEFNLGCD VHQTEHVYRV YVATFLGFGG NAARQRYEDR IFANTIQKNR LLGKQTGLTP 360
DMPYLDPCLP LDIKDEIQQN GQTIYLRGTG DFDLCRETIQ PFMNKTNETQ TSLNGVYQPP 420
IHFQNSEFYG FSEFYYCTED VLRMGGDYNA AKFTKAAKDY CATKWSILRE RFDRGLYASH 480
ADLHRLKYQC FKSAWMFEVF HRGFSFPVNY KSLKTALQVY DKEVQWTLGA ILYRTRFLPL 540
RDIQQEAFRA SHTHWRGVSF VYNHYLFSGC FLVVLLAILL YLLRLRRIHR RTPRSSSAAA 600
LWMEEGLPAQ NAPGTL 616 |
Gene Ontology | GO:0000421; C:autophagic vacuole membrane; IEA:UniProtKB-SubCell. GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW. GO:0030173; C:integral to Golgi membrane; IDA:UniProtKB. GO:0045134; F:uridine-diphosphatase activity; IDA:UniProtKB. GO:0006256; P:UDP catabolic process; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |