UniProt Accession

 LMAN2_HUMAN; Q12907; Q53HH1 

Genbank Protein ID

 U10362; AK222609; BC017263 

Genbank Nucleotide ID

 AAA19572.1; BAD96329.1; AAH17263.1 

Protein Name

 Vesicular integral-membrane protein VIP36 

Protein Synonyms/Alias

 Glycoprotein GP36b; Lectin mannose-binding 2; Vesicular integral-membrane protein 36; VIP36 

Gene Name

 LMAN2 

Gene Synonyms/Alias

 C5orf8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
126	KVHGTGKKNLHGDGI	ubiquitination	[1, 2]
300	EPSVNFLKSPKDNVD	ubiquitination	[1, 2]
303	VNFLKSPKDNVDDPT	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). 

Sequence Annotation

 DOMAIN 52 276 L-type lectin-like.
 REGION 164 166 Carbohydrate binding (By similarity).
 REGION 260 262 Carbohydrate binding (By similarity).
 METAL 162 162 Calcium (By similarity).
 METAL 164 164 Calcium; via carbonyl oxygen (By
 METAL 166 166 Calcium (By similarity).
 METAL 193 193 Calcium (By similarity).
 BINDING 96 96 Carbohydrate (By similarity).
 BINDING 131 131 Carbohydrate (By similarity).
 BINDING 190 190 Carbohydrate (By similarity).
 CARBOHYD 183 183 N-linked (GlcNAc...).
 DISULFID 202 239 By similarity.  

Keyword

 Calcium; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Lectin; Membrane; Metal-binding; Protein transport; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 356 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.
 GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR005052; Lectin_leg. 

Pfam

 PF03388; Lectin_leg-like 

SMART

  

PROSITE

 PS51328; L_LECTIN_LIKE 

PRINTS