CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006824
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cation efflux system protein CusA 
Protein Synonyms/Alias
  
Gene Name
 cusA 
Gene Synonyms/Alias
 ybdE; b0575; JW0564 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
433PDATLDNKTRWQVITacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Part of a cation efflux system that mediates resistance to copper and silver. 
Sequence Annotation
  
Keyword
 3D-structure; Cell inner membrane; Cell membrane; Complete proteome; Copper; Copper transport; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1047 AA 
Protein Sequence
MIEWIIRRSV ANRFLVLMGA LFLSIWGTWT IINTPVDALP DLSDVQVIIK TSYPGQAPQI 60
VENQVTYPLT TTMLSVPGAK TVRGFSQFGD SYVYVIFEDG TDPYWARSRV LEYLNQVQGK 120
LPAGVSAELG PDATGVGWIY EYALVDRSGK HDLADLRSLQ DWFLKYELKT IPDVAEVASV 180
GGVVKEYQVV IDPQRLAQYG ISLAEVKSAL DASNQEAGGS SIELAEAEYM VRASGYLQTL 240
DDFNHIVLKA SENGVPVYLR DVAKVQIGPE MRRGIAELNG EGEVAGGVVI LRSGKNAREV 300
IAAVKDKLET LKSSLPEGVE IVTTYDRSQL IDRAIDNLSG KLLEEFIVVA VVCALFLWHV 360
RSALVAIISL PLGLCIAFIV MHFQGLNANI MSLGGIAIAV GAMVDAAIVM IENAHKRLEE 420
WQHQHPDATL DNKTRWQVIT DASVEVGPAL FISLLIITLS FIPIFTLEGQ EGRLFGPLAF 480
TKTYAMAGAA LLAIVVIPIL MGYWIRGKIP PESSNPLNRF LIRVYHPLLL KVLHWPKTTL 540
LVAALSVLTV LWPLNKVGGE FLPQINEGDL LYMPSTLPGI SAAEAASMLQ KTDKLIMSVP 600
EVARVFGKTG KAETATDSAP LEMVETTIQL KPQEQWRPGM TMDKIIEELD NTVRLPGLAN 660
LWVPPIRNRI DMLSTGIKSP IGIKVSGTVL ADIDAMAEQI EEVARTVPGV ASALAERLEG 720
GRYINVEINR EKAARYGMTV ADVQLFVTSA VGGAMVGETV EGIARYPINL RYPQSWRDSP 780
QALRQLPILT PMKQQITLAD VADIKVSTGP SMLKTENARP TSWIYIDARD RDMVSVVHDL 840
QKAIAEKVQL KPGTSVAFSG QFELLERANH KLKLMVPMTL MIIFVLLYLA FRRVGEALLI 900
ISSVPFALVG GIWLLWWMGF HLSVATGTGF IALAGVAAEF GVVMLMYLRH AIEAVPSLNN 960
PQTFSEQKLD EALYHGAVLR VRPKAMTVAV IIAGLLPILW GTGAGSEVMS RIAAPMIGGM 1020
ITAPLLSLFI IPAAYKLMWL HRHRVRK 1047 
Gene Ontology
 GO:0016021; C:integral to membrane; IDA:EcoCyc.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005507; F:copper ion binding; IGI:EcoCyc.
 GO:0005375; F:copper ion transmembrane transporter activity; IGI:EcoCyc.
 GO:0015080; F:silver ion transmembrane transporter activity; IMP:EcoCyc.
 GO:0006878; P:cellular copper ion homeostasis; IGI:EcoCyc.
 GO:0060003; P:copper ion export; IGI:EcoCyc.
 GO:0010273; P:detoxification of copper ion; IGI:EcoCyc.
 GO:0015679; P:plasma membrane copper ion transport; IGI:EcoCyc.
 GO:0010272; P:response to silver ion; IMP:EcoCyc. 
Interpro
 IPR027463; AcrB_DN_DC_subdom.
 IPR001036; Acrflvin-R.
 IPR004763; CzcA/CusA/SilA/NccA/HelA/CnrA. 
Pfam
 PF00873; ACR_tran 
SMART
  
PROSITE
  
PRINTS
 PR00702; ACRIFLAVINRP.