UniProt Accession

 CENPO_HUMAN; Q9BU64; B2RDC0; D6W536; Q53T55; Q96JV3 

Genbank Protein ID

 AK027859; AK315483; AC012073; AC013459; CH471053; CH471053; BC002870 

Genbank Nucleotide ID

 BAB55414.1; BAG37867.1; AAY14786.1; EAX00742.1; EAX00743.1; AAH02870.1 

Protein Name

 Centromere protein O 

Protein Synonyms/Alias

 CENP-O; Interphase centromere complex protein 36 

Gene Name

 CENPO 

Gene Synonyms/Alias

 ICEN36; MCM21R 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	TQVSRSRKQSEELQS	ubiquitination	[1]
290	VFASFTRKGEKLDMS	ubiquitination	[2]
293	SFTRKGEKLDMSLVS	ubiquitination	[2]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. 

Sequence Annotation

  

Keyword

 Alternative splicing; Centromere; Chromosome; Coiled coil; Complete proteome; Kinetochore; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0051301; P:cell division; IEA:InterPro.
 GO:0034080; P:CENP-A containing nucleosome assembly at centromere; TAS:Reactome.
 GO:0007059; P:chromosome segregation; IEA:InterPro.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome. 

Interpro

 IPR018464; Centromere_CenpO. 

Pfam

 PF09496; CENP-O 

SMART

  

PROSITE

  

PRINTS