CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040029
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Superkiller viralicidic activity 2-like 2 
Protein Synonyms/Alias
  
Gene Name
 SKIV2L2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
33PRVGKAAKEYPFILDubiquitination[1, 2]
91VIFTSPIKALSNQKYubiquitination[1, 2, 3]
257RDAGDLAKGDQKGRKubiquitination[4]
278SNVFKIVKMIMERNFubiquitination[1]
296IIFSFSKKDCEAYALubiquitination[1]
307AYALQMTKLDFNTDEubiquitination[1]
316DFNTDEEKKMVEEVFubiquitination[4]
317FNTDEEKKMVEEVFSubiquitination[1]
402VLFTNARKFDGKDFRubiquitination[1]
406NARKFDGKDFRWISSubiquitination[1, 2]
486NPEYMLEKSFYQFQHubiquitination[1, 2, 4, 5]
505PGVVEKVKNSEEQYNubiquitination[1]
513NSEEQYNKIVIPNEEubiquitination[1, 4]
537QQLAKLGKEIEEYIHubiquitination[1]
545EIEEYIHKPKYCLPFacetylation[6]
647SVRLYIPKDLRPVDNubiquitination[1]
660DNRQSVLKSIQEVQKubiquitination[1, 3]
667KSIQEVQKRFPDGIPubiquitination[1]
695GLKKVIQKVEAFEHRacetylation[2]
695GLKKVIQKVEAFEHRubiquitination[1, 2]
732AQIAIDIKSAKRELKubiquitination[1]
751VLQMDELKCRKRVLRubiquitination[1]
772SSDVIEMKGRVACEIubiquitination[1, 2, 4, 5]
921GNTELENKFAEGITKubiquitination[1, 2, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 941 AA 
Protein Sequence
MEGASRVCRQ GRVALPAEED YLPLKPRVGK AAKEYPFILD AFQREAIQCV DNNQSVLVSA 60
HTSAGKTVCA EYAIALALRE KQRVIFTSPI KALSNQKYRE MYEEFQDVGL MTGDVTINPT 120
ASCLVMTTEI LRSMLYRGSE VMREVAWVIF DEIHYMRDSE RGVVWEETII LLPDNVHYVF 180
LSATIPNARQ FAEWICHLHK QPCHVIYTDY RPTPLQHYIF PAGGDGLHLV VDENGDFRED 240
NFNTAMQVLR DAGDLAKGDQ KGRKGGTKGP SNVFKIVKMI MERNFQPVII FSFSKKDCEA 300
YALQMTKLDF NTDEEKKMVE EVFSNAIDCL SDEDKKLPQV EHVLPLLKRG IGIHHGGLLP 360
ILKETIEILF SEGLIKALFA TETFAMGINM PARTVLFTNA RKFDGKDFRW ISSGEYIQMS 420
GRAGRRGMDD RGIVILMVDE KMSPTIGKQL LKGSADPLNS AFHLTYNMVL NLLRVEEINP 480
EYMLEKSFYQ FQHYRAIPGV VEKVKNSEEQ YNKIVIPNEE SVVIYYKIRQ QLAKLGKEIE 540
EYIHKPKYCL PFLQPGRLVK VKNEGDDFGW GVVVNFSKKS NVKPNSGELD PLYVVEVLLR 600
CSKESLKNSA TEAAKPAKPD EKGEMQVVPV LVHLLSAISS VRLYIPKDLR PVDNRQSVLK 660
SIQEVQKRFP DGIPLLDPID DMGIQDQGLK KVIQKVEAFE HRMYSHPLHN DPNLETVYTL 720
CEKKAQIAID IKSAKRELKK ARTVLQMDEL KCRKRVLRRL GFATSSDVIE MKGRVACEIS 780
SADELLLTEM MFNGLFNDLS AEQATALLSC FVFQENSSEM PKLTEQLAGP LRQMQECAKR 840
IAKVSAEAKL EIDEETYLSS FKPHLMDVVY TWATGATFAH ICKMTDVFEG SIIRCMRRLE 900
ELLRQMCQAA KAIGNTELEN KFAEGITKIK RDIVFAASLY L 941 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR012961; DSH_C.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR016438; RNA_helicase_ATP-dep_SK12/DOB1.
 IPR025696; rRNA_proc-arch_dom. 
Pfam
 PF00270; DEAD
 PF08148; DSHCT
 PF00271; Helicase_C
 PF13234; rRNA_proc-arch 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS