CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024303
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoprotein TPR 
Protein Synonyms/Alias
 Megator; Nuclear envelope antigen Bx34 
Gene Name
 Mtor 
Gene Synonyms/Alias
 CG8274 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
270ATEEYVGKLKKELDAacetylation[1]
711ELTSSNCKLMNTTEFacetylation[1]
720MNTTEFQKEQIELLHacetylation[1]
728EQIELLHKNIGTYKQacetylation[1]
749ERTKNYEKTIIKHEQacetylation[1]
753NYEKTIIKHEQTVHLacetylation[1]
762EQTVHLLKDEMMAAHacetylation[1]
1206RNNEQLLKIIKFLRKacetylation[1]
1342SLRTEAIKWRQRANAacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleoporin- associated regions (NARs) that define transcriptionally active regions of the genome. Associates with extended chromosomal regions that alternate between domains of high density binding with those of low occupancy. Preferentially binds to NARs of the male X chromosome. Acts also as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like Mad2 and Mps1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. 
Sequence Annotation
  
Keyword
 Activator; Cell cycle; Cell division; Centromere; Chromatin regulator; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; DNA-binding; Kinetochore; Membrane; Mitosis; mRNA transport; Nuclear pore complex; Nucleus; Protein transport; Reference proteome; Transcription; Transcription regulation; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2346 AA 
Protein Sequence
MDLSGPQTLN NILQPDELKL VPEDVQKKLS EYINNFSDEY CKNRAAANRL AEAEQKKEEL 60
ENKMEDYLVK FTSFELNVNE LRTHLDQMSS ERVNLMDTIA KGEQTISQLR KEKASVVEER 120
DSMMKVIERQ QAELERLKQD LHTYQQQLSS AIAAKCEAIA RVDEIQSKEV ALELKENRME 180
SERDMLHKEI LLISGDLNKS NAELQNIRRE HTINTMQLQS CLKEKTESLK LMQEQYEQAV 240
KTIGELTSKI EMQNDTAFKQ NQATEEYVGK LKKELDAKEK LFEIFKSTES DHLIQREELL 300
QGISEIKRLL EEAEEQCAQL TEQMETMKQK HSAELDEQNK KIQAMEQELA SANDLLKQAR 360
ESNLESAICQ LAPSAAVASR LIRSDLSLTE LYSMYAKSSE ELEMRNCEIE QLKLQLKSII 420
AEISESAPIL EKQNSDYQKM KETNSELLRE HDELLQNKLC LERELERALS TLNHNQNENK 480
KLKQTHTDLS RQVCMLLDEL NCIRAGVKHV RIQPTRQLPT SESLISDNLV TFSSIEELVD 540
RNTYLLNMSR ELTELLEASE KNQDKMLLEQ SKNHIRKLDA RFAELEDLLT QKNNTVTTLL 600
SKCDRYKKLY FAAQKKLGQN TVDLDDSNLE PNDSALDTSE QPAANFEESR KLEKRVRQLE 660
QQLEGEVKKY ASLKENYDYY TSEKRKNDAL AQEQFDSMRK EVRELTSSNC KLMNTTEFQK 720
EQIELLHKNI GTYKQQVTTL EERTKNYEKT IIKHEQTVHL LKDEMMAAHR KHAAADAEAQ 780
SLRQENRILR DTSSRLQIEK ETYHREQQSQ SLLLNSLEFI KTNLERSEME GRQRLEQRLD 840
DTVRELAAQR RHFQEEEEKF RESINEFKRQ AETAIKLKDE EKQLADKWQA ELTSVREELA 900
EKVNKVNELS KKLQEVLTPT LNDNPITAAN KRAREFELKL DQATVEIESL TKELAKTREH 960
GEQFYKMSQS AESEIKRLHE LHGELVAKQE EEIKKLRSSE AELKTRISDL EAEAMLSNVT 1020
EQSKTVNQSG QLKSAQDDLK SLLEKLTEAN CTIRTLRSEN TSLVESLNAA EVKYANGMIQ 1080
HSADIQELTR YKAEFFKAND ELNQLKSGRE SLQAAYDELL RSNAEAQKLL DKEREESEKR 1140
VADLHALNSN LHDQIEALAS KLAVLASQSQ NPNSSLNESA MDGDQSLNAS GLTAAEEGRN 1200
NEQLLKIIKF LRKEKDLFAA KLDILKAENA RLISEHAIQQ KKVDELNGYL NQERAKSQTD 1260
VVSANKHEEV LRKIETLNAI TDSNRILREE RNALTLRVAE LTDRISSVEK ELFPLQCSNK 1320
ELTSKIEEIN VENTSLRTEA IKWRQRANAL VEKSNRNPEE FKRLQAEREH LAKLLTAEKE 1380
LNKKQSDELT VLKQRMNTEI PMLNKQMQIL DEARKKQVDE FTNLKQNNTR QTQDIMELKN 1440
RLLQKEEELL KANEELETKD KTIADKETKE LQLRKLAKRY KDFYIGLQSQ GGGTESAAEL 1500
EKVRSELEEV NNQLRALKDE HEKITKECDE VKKRTEPETD TSAIRQEYKA KLDKLVVDLT 1560
VARTDLVNQE TTFAGTKSSY DETIARLEKE LQENIAANKD INQRLTRENE SLHMRINQLT 1620
RQLGSQQSTK PSTSSVAEKG NISESSPRTA NVKPMSGSAT VQQSATVTPW RGGETPLASI 1680
RPISVQNSRT AAILPTSQQP PAGSSTSTSS SSSSSSTSTT SAAGGGSSAV AQTALVPPQQ 1740
QVHTTGSAAL ESMASSSPTS SHTDYMPSTS SASVAVAAIP PMGASSAAES SQEAESIQHP 1800
QQNDSQLFVG GAQQQVVALV SPRVEGSSSS SSSTSVPTAT APSIQDGGSQ SQQPSTSGSS 1860
SSSSTVVSSH SRHTPSSSNV TTTQAGCSSQ GIKRPRDIEG DSSTGTEEGV AEKMSKITKR 1920
LRGPMHSGEL SAGHIGDSGM DVDQMPTSSQ RDQEDDIQVV DSDDEEDVLA DADDGPIDGG 1980
EAEQEGYEDS YEQDNEMDDN EGGDDDNDIA VDAQDNNEVD IEVPEQHMQA QEESQSLDNQ 2040
AIATASASTQ ENNQSQAITS GSGESSNPVT LPQAEASNWK QAAASTSTAA ARRNESSVEI 2100
VSSPQVSNFC EQPARLESAE VDGTAEVAGG APHESAGPSD TGAASASSPQ KQSEAGESSG 2160
SDALKAADDG GDHADGTDNA READEAFAEE TMATGQGEDS QPLGNDNPNV GTSQSEVSHN 2220
QANLGEGNPT EDSEGADGVS SEGEKQAVGV EEEGREAEAT SPSENTRFRT LRSAVPTRRG 2280
HRAMRGGSPN SQNRPQRIVW QRDTSPGNIQ QNQMSANNNR FAQRTRNRRP IRRPPPNNFN 2340
NGGRFP 2346 
Gene Ontology
 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0070090; C:metaphase plate; IDA:UniProtKB.
 GO:0030496; C:midbody; IDA:UniProtKB.
 GO:0072686; C:mitotic spindle; IDA:UniProtKB.
 GO:0005719; C:nuclear euchromatin; IDA:UniProtKB.
 GO:0042405; C:nuclear inclusion body; IDA:UniProtKB.
 GO:0005652; C:nuclear lamina; IDA:UniProtKB.
 GO:0016363; C:nuclear matrix; IDA:UniProtKB.
 GO:0031965; C:nuclear membrane; IDA:UniProtKB.
 GO:0005643; C:nuclear pore; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0051233; C:spindle midzone; IDA:FlyBase.
 GO:0031490; F:chromatin DNA binding; IDA:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006338; P:chromatin remodeling; IMP:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0051781; P:positive regulation of cell division; IMP:UniProtKB.
 GO:0090316; P:positive regulation of intracellular protein transport; IMP:UniProtKB.
 GO:0045840; P:positive regulation of mitosis; IMP:UniProtKB.
 GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IMP:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
 GO:0006606; P:protein import into nucleus; IEA:InterPro.
 GO:0090235; P:regulation of metaphase plate congression; IMP:UniProtKB.
 GO:1901673; P:regulation of spindle assembly involved in mitosis; IMP:UniProtKB.
 GO:0034401; P:regulation of transcription by chromatin organization; IMP:UniProtKB.
 GO:0009408; P:response to heat; IDA:UniProtKB.
 GO:0051225; P:spindle assembly; IDA:FlyBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR012929; TPR_MLP1_2. 
Pfam
 PF07926; TPR_MLP1_2 
SMART
  
PROSITE
  
PRINTS