CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017512
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prostaglandin reductase 2 
Protein Synonyms/Alias
 PRG-2; 15-oxoprostaglandin 13-reductase; Zinc-binding alcohol dehydrogenase domain-containing protein 1 
Gene Name
 PTGR2 
Gene Synonyms/Alias
 ZADH1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14VLNSRPGKNGNPVAEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity). 
Sequence Annotation
 NP_BIND 165 168 NADP.
 NP_BIND 253 259 NADP.
 NP_BIND 287 289 NADP.
 REGION 99 100 Substrate binding.
 REGION 288 290 Substrate binding.
 BINDING 192 192 NADP.
 BINDING 208 208 NADP.
 BINDING 231 231 NADP.
 BINDING 337 337 NADP.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 351 AA 
Protein Sequence
MIVQRVVLNS RPGKNGNPVA ENFRMEEVYL PDNINEGQVQ VRTLYLSVDP YMRCRMNEDT 60
GTDYITPWQL SQVVDGGGIG IIEESKHTNL TKGDFVTSFY WPWQTKVILD GNSLEKVDPQ 120
LVDGHLSYFL GAIGMPGLTS LIGIQEKGHI TAGSNKTMVV SGAAGACGSV AGQIGHFLGC 180
SRVVGICGTH EKCILLTSEL GFDAAINYKK DNVAEQLRES CPAGVDVYFD NVGGNISDTV 240
ISQMNENSHI ILCGQISQYN KDVPYPPPLS PAIEAIQKER NITRERFLVL NYKDKFEPGI 300
LQLSQWFKEG KLKIKETVIN GLENMGAAFQ SMMTGGNIGK QIVCISEEIS L 351 
Gene Ontology
 GO:0005737; C:cytoplasm; NAS:UniProtKB.
 GO:0036132; F:13-prostaglandin reductase activity; IEA:EC.
 GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IDA:UniProtKB.
 GO:0006693; P:prostaglandin metabolic process; IDA:UniProtKB. 
Interpro
 IPR013149; ADH_C.
 IPR002085; ADH_SF_Zn-type.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00107; ADH_zinc_N 
SMART
  
PROSITE
  
PRINTS