CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013079
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FERM domain-containing protein 8 
Protein Synonyms/Alias
  
Gene Name
 Frmd8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
196AACTLREKLDSFLPAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 DOMAIN 30 377 FERM.
 MOD_RES 20 20 Phosphoserine.
 MOD_RES 21 21 Phosphoserine.
 MOD_RES 420 420 Phosphothreonine.
 MOD_RES 440 440 Phosphoserine (By similarity).
 MOD_RES 447 447 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 466 AA 
Protein Sequence
MEGAEGNAGQ PGPAERSHRS SVSSVGARAA DVLVYLADDT VVPLAVENLS SISAHELHRA 60
VREVLQLPDV ALEAFALWLV SPLLEVQLKP KHQPYKLGRQ WPELLLRFTN ASDDDVAMDE 120
PSLQFRRNVF FPRRRELQIH DEEVLRLLYE EAKGNVLTAR YPCDLEDCEV LGGLVCRVQL 180
GPYQPGQPAA CTLREKLDSF LPAHLCKRGH GLFAAFRGRG AKTGPGEQGL LNAYRQVKEV 240
TGNNSEREAT LGSHYRAYLL KCHELPFYGC AFFHGEVDKP AQGFLHRGGR KPVTVAISLE 300
GVHVIDNREK HVLLGLRFQE LSWDHTSPEE EEPVLWLEFD GDSEGTPVNK LLRIYSKQAE 360
LMSGLIEYCI ELSQAAEPTL SQESASGPHE APSPSPPPTQ RPKLRRQGSV VCSRIQHLST 420
IDYVEDGKGI KRVKPKRTTS FFSRQLSSSQ GSYTVVQPTD DSLEQS 466 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro. 
Interpro
 IPR019749; Band_41_domain.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR000299; FERM_domain. 
Pfam
 PF00373; FERM_M 
SMART
 SM00295; B41 
PROSITE
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3 
PRINTS