| Tag | Content |
|---|
| CPLM ID | CPLM-001543 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Netrin receptor UNC5C |
Protein Synonyms/Alias | Protein unc-5 homolog 3; Protein unc-5 homolog C |
Gene Name | UNC5C |
Gene Synonyms/Alias | UNC5H3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 448 | GFQPVNIKAARQDLL | ubiquitination | [1] | | 481 | ALHDVSDKIPMTNSP | ubiquitination | [1] | | 497 | LDPLPNLKIKVYNTS | ubiquitination | [1] | | 519 | DLSEFTSKLSPQMTQ | ubiquitination | [1] | | 537 | ENEALSLKNQSLARQ | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). |
Sequence Annotation | DOMAIN 62 159 Ig-like.
DOMAIN 161 256 Ig-like C2-type.
DOMAIN 260 314 TSP type-1 1.
DOMAIN 316 368 TSP type-1 2.
DOMAIN 528 634 ZU5.
DOMAIN 850 929 Death.
REGION 694 712 Interaction with DCC (By similarity).
MOD_RES 568 568 Phosphotyrosine (By similarity).
CARBOHYD 236 236 N-linked (GlcNAc...) (Potential).
CARBOHYD 361 361 N-linked (GlcNAc...) (Potential).
DISULFID 83 142 By similarity.
DISULFID 188 239 By similarity.
DISULFID 272 309 By similarity.
DISULFID 276 313 By similarity.
DISULFID 287 299 By similarity. |
Keyword | Alternative splicing; Apoptosis; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 931 AA |
Protein Sequence | MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP 60
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR 120
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL 180
EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV 240
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE 300
GQSVQKIACT TLCPVDGRWT PWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK 360
NCTDGLCMQS FIYPISTEQR TQNEYGFSSA PDSDDVALYV GIVIAVIVCL AISVVVALFV 420
YRKNHRDFES DIIDSSALNG GFQPVNIKAA RQDLLAVPPD LTSAAAMYRG PVYALHDVSD 480
KIPMTNSPIL DPLPNLKIKV YNTSGAVTPQ DDLSEFTSKL SPQMTQSLLE NEALSLKNQS 540
LARQTDPSCT AFGSFNSLGG HLIVPNSGVS LLIPAGAIPQ GRVYEMYVTV HRKETMR 597 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:Compara. GO:0005042; F:netrin receptor activity; TAS:ProtInc. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0007411; P:axon guidance; TAS:Reactome. GO:0007420; P:brain development; TAS:ProtInc. GO:0043065; P:positive regulation of apoptotic process; IEA:Compara. GO:0030334; P:regulation of cell migration; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |