CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024357
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Formin-like protein 2 
Protein Synonyms/Alias
 Protein Man 
Gene Name
 Fmnl2 
Gene Synonyms/Alias
 Kiaa1902; Man 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
355GLDEYLDKLKHTESDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics (By similarity). 
Sequence Annotation
 DOMAIN 23 469 GBD/FH3.
 DOMAIN 615 1006 FH2.
 DOMAIN 1038 1077 DAD.
 MOD_RES 171 171 Phosphoserine (By similarity).
 LIPID 2 2 N-myristoyl glycine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Lipoprotein; Myristate; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1086 AA 
Protein Sequence
MGNAGSMDSQ QTDFKAHNVP LKLPMPEPGE LEERFAIVLN AMNLPPDKAR LLRQYDNEKK 60
WELICDQERF QVKNPPHTYI QKLKGYLDPA VTRKKFRRRV QESTQVLREL EISLRTNHIG 120
WVREFLNEEN KGLDVLVEYL SFAQYAVTFD FESVESTMES TVDKSKPWSR SIEDLHRGSN 180
LPSPVGNSVS RSGRHSALRY NTLPSRRTLK NSRLVSKKDD VHVCIMCLRA IMNYQYGFNM 240
VMSHPHAVNE IALSLNNKNP RTKALVLELL AAVCLVRGGH EIILSAFDNF KEVCGEKQRF 300
EKLMEHFRNE DNNIDFMVAS MQFINIVVHS VEDMNFRVHL QYEFTKLGLD EYLDKLKHTE 360
SDKLQVQIQA YLDNVFDVGA LLEDAETKNA ALERVEELEE NISHLSEKLQ DTENEAMSKI 420
VELEKQLMQR NKELDVVREI YKDANTQVHT LRKMVKEKEE AIQRQSTLEK KIHELEKQGT 480
IKIQKKGDGD IAILPVMASG TLSTGSELAV GNYVGSVPGA TTSGPSVPPP PPLPPSSDTS 540
EAAQNGTASP PMSPPPPPPP PPPPPPPPPP PLPGPAAETS PAPPLPPPPP PSAPPLPGTS 600
SPTVVFNSGL AAVKIKKPIK TKFRMPVFNW VALKPNQING TVFNEIDDER ILEDLNVDEF 660
EEIFKTKAQG PAIDLSSSKQ KITQKASSKV TLLEANRAKN LAITLRKAGK SADEICKAIH 720
VFDLKTLPVD FVECLMRFLP TENEVKVLRL YERERKPLEN LSDEDRFMMQ FSKIERLLQK 780
MTIMAFIGNF TESIQMLTPQ LHAIIAASVS IKSSQKLKKI LEIILALGNY MNSSKRGAVY 840
GFKLQSLDLL LDTKSTDRKQ TLLHYISNVV KEKYQQVTLF YNELHYVEKA AAVSLENVLL 900
DVKELQRGMD LTKREYTMHD HNTLLKEFLL HNEGKLKKLQ EDAKIAQDAF DDVVKYFGEN 960
PKTTPPSVFF PVFVRFVKAY KQAEEENELR KKQEQALMEK LLEQEALMEQ QDAKSPSHKS 1020
KRQQQELIAE LRRRQVKDNR HVYEGKDGAI EDIITALKKN NITKFPNVHS RVRISSSTPV 1080
VEDTQS 1086 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030866; P:cortical actin cytoskeleton organization; ISS:UniProtKB.
 GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB. 
Interpro
 IPR003104; Actin-bd_FH2/DRF_autoreg.
 IPR016024; ARM-type_fold.
 IPR010472; Drf_FH3.
 IPR010473; Drf_GTPase-bd.
 IPR015425; FH2_actin-bd.
 IPR014768; GTPase-bd/formin_homology_3. 
Pfam
 PF06367; Drf_FH3
 PF06371; Drf_GBD
 PF02181; FH2 
SMART
 SM00498; FH2 
PROSITE
 PS51231; DAD
 PS51444; FH2
 PS51232; GBD_FH3 
PRINTS