| Tag | Content |
|---|
| CPLM ID | CPLM-022208 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrator complex subunit 7 |
Protein Synonyms/Alias | Int7 |
Gene Name | INTS7 |
Gene Synonyms/Alias | C1orf73 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 105 | LNVDEFVKRIFSVIH | ubiquitination | [1] | | 277 | RLAIQDLKLLANKTP | ubiquitination | [1] | | 672 | GRISNQMKQSMEEFR | ubiquitination | [1] | | 853 | SKSGQDYKIPIDNMT | ubiquitination | [1] | | 915 | PRTTIFVKSLEDPYS | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. |
Sequence Annotation | MOD_RES 525 525 Phosphothreonine (By similarity).
MOD_RES 527 527 Phosphotyrosine (By similarity). |
Keyword | Alternative splicing; Chromosome; Complete proteome; DNA damage; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 962 AA |
Protein Sequence | MASNSTKSFL ADAGYGEQEL DANSALMELD KGLRSGKLGE QCEAVVRFPR LFQKYPFPIL 60
INSAFLKLAD VFRVGNNFLR LCVLKVTQQS EKHLEKILNV DEFVKRIFSV IHSNDPVARA 120
ITLRMLGSLA SIIPERKNAH HSIRQSLDSH DNVEVEAAVF AAANFSAQSK DFAVGICNKI 180
SEMIQGLATP VDLKLKLIPI LQHMHHDAIL ASSARQLLQQ LVTSYPSTKM VIVSLHTFTL 240
LAASSLVDTP KQIQLLLQYL KNDPRKAVKR LAIQDLKLLA NKTPHTWSRE NIQALCECAL 300
QTPYDSLKLG MLSVLSTLSG TIAIKHYFSI VPGNVSSSPR SSDLVKLAQE CCYHNNRGIA 360
AHGVRVLTNI TVSCQEKDLL ALEQDAVFGL ESLLVLCSQD DSPGAQATLK IALNCMVKLA 420
KGRPHLSQSV VETLLTQLHS AQDAARILMC HCLAAIAMQL PVLGDGMLGD LMELYKVIGR 480
SATDKQQELL VSLATVIFVA SQKALSVESK AVIKQQLESV SNGWTVYRIA RQASRMGNHD 540
MAKELYQSLL TQVASEHFYF WLNSLKEFSH AEQCLTGLQE ENYSSALSCI AESLKFYHKG 600
IASLTAASTP LNPLSFQCEF VKLRIDLLQA FSQLICTCNS LKTSPPPAIA TTIAMTLGND 660
LQRCGRISNQ MKQSMEEFRS LASRYGDLYQ ASFDADSATL RNVELQQQSC LLISHAIEAL 720
ILDPESASFQ EYGSTGTAHA DSEYERRMMS VYNHVLEEHT ACLCNAIIAL LKVPLSFQRY 780
FFQKLQSTSI KLALSPSPRN PAEPIAVQNN QQLALKVEGV VQHGSKPGLF RKIQSVCLNV 840
SSTLQSKSGQ DYKIPIDNMT NEMEQRVEPH NDYFSTQFLL NFAILGTHNI TVESSVKDAN 900
GIVWKTGPRT TIFVKSLEDP YSQQIRLQQQ QAQQPLQQQQ QRNAYTRF 948 |
Gene Ontology | |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |