UniProt Accession

 COX7C_HUMAN; P15954; Q6NR81 

Genbank Protein ID

 X16560; AF067639; AF067638; BT007098; BC001005; BC007498 

Genbank Nucleotide ID

 CAA34559.1; AAC73062.1; AAC73062.1; AAP35762.1; AAH01005.1; AAH07498.1 

Protein Name

 Cytochrome c oxidase subunit 7C, mitochondrial 

Protein Synonyms/Alias

 Cytochrome c oxidase polypeptide VIIc 

Gene Name

 COX7C 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
25	HYEEGPGKNLPFSVE	ubiquitination	[1, 2]
34	LPFSVENKWSLLAKM	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 

Sequence Annotation

  

Keyword

 Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 63 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR023284; Cyt_c_Oxase_suVIIc_dom.
 IPR004202; Cyt_c_oxidsae_su7c. 

Pfam

 PF02935; COX7C 

SMART

  

PROSITE

  

PRINTS