UniProt Accession

 CRBA1_HUMAN; P05813; Q13633; Q14CM9 

Genbank Protein ID

 M14306; M14301; M14302; M14303; M14304; M14305; BC069537; BC113693; U59058 

Genbank Nucleotide ID

 AAA52107.1; AAA52107.1; AAA52107.1; AAA52107.1; AAA52107.1; AAA52107.1; AAH69537.1; AAI13694.1; AAC50971.1 

Protein Name

 Beta-crystallin A3 

Protein Synonyms/Alias

 Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form 

Gene Name

 CRYBA1 

Gene Synonyms/Alias

 CRYB1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	DQENFQGKRMEFTSS	methylation	[1]
122	PICSANHKESKMTIF	acetylation	[2]
125	SANHKESKMTIFEKE	acetylation	[2]
131	SKMTIFEKENFIGRQ	acetylation	[2]

Reference

 [1] Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility?
 Wilmarth PA, Tanner S, Dasari S, Nagalla SR, Riviere MA, Bafna V, Pevzner PA, David LL.
 J Proteome Res. 2006 Oct;5(10):2554-66. [PMID: 17022627]
 [2] Shotgun identification of protein modifications from protein complexes and lens tissue.
 MacCoss MJ, McDonald WH, Saraf A, Sadygov R, Clark JM, Tasto JJ, Gould KL, Wolters D, Washburn M, Weiss A, Clark JI, Yates JR 3rd.
 Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7900-5. [PMID: 12060738] 

Functional Description

 Crystallins are the dominant structural components of the vertebrate eye lens. 

Sequence Annotation

 DOMAIN 31 70 Beta/gamma crystallin 'Greek key' 1.
 DOMAIN 71 117 Beta/gamma crystallin 'Greek key' 2.
 DOMAIN 124 165 Beta/gamma crystallin 'Greek key' 3.
 DOMAIN 166 214 Beta/gamma crystallin 'Greek key' 4.
 REGION 1 30 N-terminal arm.
 REGION 118 123 Connecting peptide.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 82 82 S-glutathionyl cysteine; alternate.
 MOD_RES 82 82 S-methylcysteine; alternate.
 MOD_RES 117 117 S-glutathionyl cysteine; alternate.
 MOD_RES 117 117 S-methylcysteine; alternate.  

Keyword

 Acetylation; Alternative initiation; Cataract; Complete proteome; Direct protein sequencing; Eye lens protein; Glutathionylation; Methylation; Oxidation; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0007601; P:visual perception; IMP:UniProtKB. 

Interpro

 IPR001064; Beta/gamma_crystallin.
 IPR011024; G_crystallin-rel. 

Pfam

 PF00030; Crystall 

SMART

 SM00247; XTALbg 

PROSITE

 PS50915; CRYSTALLIN_BETA_GAMMA 

PRINTS

 PR01367; BGCRYSTALLIN.