CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032840
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Potassium voltage-gated channel subfamily H member 2 
Protein Synonyms/Alias
 Voltage-gated potassium channel subfamily H isoform 3.1 
Gene Name
 KCNH2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
70RAKTFRLKLPALLALubiquitination[1, 2]
248TLNFVDLKGDPFLASubiquitination[3]
293ADVLPEYKLQAPRIHubiquitination[1, 3]
645RSLLQHCKPFRGATKubiquitination[1]
661CLRALAMKFKTTHAPubiquitination[1]
801SFRRRTDKDTEQPGEubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1063 AA 
Protein Sequence
MSSHSAGSCF LCLVDVVPVK NEDGAVIMFI LNFEVVMEKD MVGSPAHDTN HRGPPTSWLA 60
PGRAKTFRLK LPALLALTAR ESSVRSGGAG GAGAPGAVVV DVDLTPAAPS SESLALDEVT 120
AMDNHVAGLG PAEERRALVG PGSPPRSAPG QLPSPRAHSL NPDASGSSCS LARTRSRESC 180
ASVRRASSAD DIEAMRAGVL PPPPRHASTG AMHPLRSGLL NSTSDSDLVR YRTISKIPQI 240
TLNFVDLKGD PFLASPTSDR EIIAPKIKER THNVTEKVTQ VLSLGADVLP EYKLQAPRIH 300
RWTILHYSPF KAVWDWLILL LVIYTAVFTP YSAAFLLKET EEGPPATECG YACQPLAVVD 360
LIVDIMFIVD ILINFRTTYV NANEEVVSHP GRIAVHYFKG WFLIDMVAAI PFDLLIFGSG 420
SEELIGLLKT ARLLRLVRVA RKLDRYSEYG AAVLFLLMCT FALIAHWLAC IWYAIGNMEQ 480
PHMDSRIGWL HNLGDQIGKP YNSSGLGGPS IKDKYVTALY FTFSSLTSVG FGNVSPNTNS 540
EKIFSICVML IGSLMYASIF GNVSAIIQRL YSGTARYHTQ MLRVREFIRF HQIPNPLRQR 600
LEEYFQHAWS YTNGIDMNAV LKGFPECLQA DICLHLNRSL LQHCKPFRGA TKGCLRALAM 660
KFKTTHAPPG DTLVHAGDLL TALYFISRGS IEILRGDVVV AILGKNDIFG EPLNLYARPG 720
KSNGDVRALT YCDLHKIHRD DLLEVLDMYP EFSDHFWSSL EITFNLRDTN MIPGSPGSTE 780
LEGGFSRQRK RKLSFRRRTD KDTEQPGEVS ALGPGRAGAG PSSRGRPGGP WGESPSSGPS 840
SPESSEDEGP GRSSSPLRLV PFSSPRPPGE PPGGEPLMED CEKSSDTCNP LSGAFSGVSN 900
IFSFWGDSRG RQYQELPRCP APTPSLLNIP LSSPGRRPRG DVESRLDALQ RQLNRLETRL 960
SADMATVLQL LQRQMTLVPP AYSAVTTPGP GPTSTSPLLP VSPLPTLTLD SLSQVSQFMA 1020
CEELPPGAPE LPQEGPTRRL SLPGQLGALT SQPLHRHGSD PGS 1063 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. 
Interpro
 IPR018490; cNMP-bd-like.
 IPR000595; cNMP-bd_dom.
 IPR005821; Ion_trans_dom.
 IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
 IPR003967; K_chnl_volt-dep_ERG.
 IPR014710; RmlC-like_jellyroll. 
Pfam
 PF00027; cNMP_binding
 PF00520; Ion_trans 
SMART
 SM00100; cNMP 
PROSITE
 PS50042; CNMP_BINDING_3 
PRINTS
 PR01463; EAGCHANLFMLY.
 PR01470; ERGCHANNEL.