UniProt Accession

 ZFY27_HUMAN; Q5T4F4; B7Z3S0; B7Z404; B7Z626; G8JLC3; G8JLF0; J3KP98; Q5T4F1; Q5T4F2; Q5T4F3; Q8N1K0; Q8N6D6; Q8NCA0; Q8NDE4; Q96M08 

Genbank Protein ID

 AK057481; AK097945; AK074876; AK296295; AK296588; AK299735; AL358938; AL358938; AL358938; BC030621; AL834235 

Genbank Nucleotide ID

 BAB71506.1; BAC05200.1; BAC11260.1; BAH12306.1; BAH12390.1; BAH13112.1; CAI14270.1; CAI14271.1; CAI14272.1; AAH30621.2; CAD38913.2 

Protein Name

 Protrudin 

Protein Synonyms/Alias

 Zinc finger FYVE domain-containing protein 27 

Gene Name

 ZFYVE27 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	EIYLEPLKDAGDGVR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation. 

Sequence Annotation

 ZN_FING 344 410 FYVE-type.
 REGION 51 64 Necessary for interaction with RAB11A and
 REGION 286 292 Necessary for interaction with VAPA and
 CARBOHYD 209 209 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Cell projection; Complete proteome; Disease mutation; Endoplasmic reticulum; Endosome; Glycoprotein; Hereditary spastic paraplegia; Membrane; Metal-binding; Neurodegeneration; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 411 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; ISS:UniProtKB.
 GO:0030425; C:dendrite; ISS:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0032584; C:growth cone membrane; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0031175; P:neuron projection development; IDA:UniProtKB.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; ISS:UniProtKB.
 GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB. 

Interpro

 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF01363; FYVE 

SMART

 SM00064; FYVE 

PROSITE

 PS50178; ZF_FYVE 

PRINTS