CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007862
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 3-hydroxyanthranilate 3,4-dioxygenase 
Protein Synonyms/Alias
 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD 
Gene Name
 Haao 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
184VMEPMSLKAWLESHSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity). 
Sequence Annotation
 REGION 1 160 Domain A (catalytic) (By similarity).
 REGION 161 177 Linker (By similarity).
 REGION 178 286 Domain B (By similarity).
 METAL 47 47 Iron; catalytic (By similarity).
 METAL 53 53 Iron; catalytic (By similarity).
 METAL 91 91 Iron; catalytic (By similarity).
 BINDING 43 43 Dioxygen (By similarity).
 BINDING 53 53 Substrate (By similarity).
 BINDING 95 95 Substrate (By similarity).
 BINDING 105 105 Substrate (By similarity).
 MOD_RES 9 9 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Dioxygenase; Direct protein sequencing; Iron; Metal-binding; Oxidoreductase; Phosphoprotein; Pyridine nucleotide biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 286 AA 
Protein Sequence
MERCVRVKSW VEENRASFQP PVCNKLMHRE QLKIMFVGGP NTRKDYHIEE GEEVFYQLEG 60
DMVLRVLEQG EHRDVVIRQG EIFLLPARVP HSPQRFANTM GLVIERRRME TELDGLRYYV 120
GDTEDVLFEK WFHCKDLGTQ LAPIIQEFFH SEQYRTGKPN PDQLLKEPPF PLSTRSVMEP 180
MSLKAWLESH SRELQAGTSL SLFGDSYETQ VIAHGQGSSK GPRQDVDVWL WQLEGSSKVT 240
MGGQCVALAP DDSLLVPAGF SYMWERAQGS VALSVTQDPA CKKPLG 286 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0031966; C:mitochondrial membrane; IDA:RGD.
 GO:0000334; F:3-hydroxyanthranilate 3,4-dioxygenase activity; IDA:RGD.
 GO:0008198; F:ferrous iron binding; IEA:HAMAP.
 GO:0005506; F:iron ion binding; IDA:RGD.
 GO:0019825; F:oxygen binding; IDA:RGD.
 GO:0043420; P:anthranilate metabolic process; IEA:HAMAP.
 GO:0034354; P:de novo NAD biosynthetic process from tryptophan; IEA:HAMAP.
 GO:0070050; P:neuron homeostasis; IEA:Compara.
 GO:0019805; P:quinolinate biosynthetic process; IEA:HAMAP.
 GO:0046874; P:quinolinate metabolic process; IDA:RGD.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0010043; P:response to zinc ion; IEA:Compara.
 GO:0006569; P:tryptophan catabolic process; IEA:HAMAP. 
Interpro
 IPR010329; 3hydroanth_dOase.
 IPR016700; 3hydroanth_dOase_met.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 
Pfam
 PF06052; 3-HAO 
SMART
  
PROSITE
  
PRINTS