CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000982
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-glucose 6-dehydrogenase 
Protein Synonyms/Alias
 UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH 
Gene Name
 UGDH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
80TNIDDAIKEADLVFIubiquitination[1]
107KGRAADLKYIEACARacetylation[2]
107KGRAADLKYIEACARubiquitination[3]
129GYKIVTEKSTVPVRAubiquitination[4]
149RIFDANTKPNLNLQVubiquitination[1]
173GTAIKDLKNPDRVLIacetylation[2]
173GTAIKDLKNPDRVLIubiquitination[1]
434RIHKKMLKPAFIFDGacetylation[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. 
Sequence Annotation
 NP_BIND 11 16 NAD.
 NP_BIND 89 93 NAD.
 NP_BIND 130 131 NAD.
 NP_BIND 276 279 NAD.
 REGION 161 165 Substrate binding.
 REGION 220 227 Substrate binding.
 REGION 260 273 Substrate binding.
 REGION 338 339 Substrate binding.
 ACT_SITE 276 276 Nucleophile.
 BINDING 36 36 NAD.
 BINDING 41 41 NAD.
 BINDING 165 165 NAD.
 BINDING 346 346 NAD.
 BINDING 442 442 Substrate.
 MOD_RES 107 107 N6-acetyllysine.
 MOD_RES 473 473 Phosphotyrosine (By similarity).  
Keyword
 3D-structure; Acetylation; Allosteric enzyme; Alternative splicing; Complete proteome; NAD; Oxidoreductase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 494 AA 
Protein Sequence
MFEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNES RINAWNSPTL PIYEPGLKEV 60
VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS 120
NGYKIVTEKS TVPVRAAESI RRIFDANTKP NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI 180
GGDETPEGQR AVQALCAVYE HWVPREKILT TNTWSSELSK LAANAFLAQR ISSINSISAL 240
CEATGADVEE VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW 300
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE 360
GAHLHIYDPK VPREQIVVDL SHPGVSEDDQ VSRLVTISKD PYEACDGAHA VVICTEWDMF 420
KELDYERIHK KMLKPAFIFD GRRVLDGLHN ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP 480
KFSLQDPPNK KPKV 494 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0009055; F:electron carrier activity; TAS:UniProtKB.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0003979; F:UDP-glucose 6-dehydrogenase activity; TAS:Reactome.
 GO:0001702; P:gastrulation with mouth forming second; IEA:Compara.
 GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:ProtInc.
 GO:0006011; P:UDP-glucose metabolic process; TAS:ProtInc.
 GO:0006065; P:UDP-glucuronate biosynthetic process; TAS:Reactome.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR016040; NAD(P)-bd_dom.
 IPR017476; Nucleotide_sugar_DH.
 IPR014027; UDP-Glc/GDP-Man_DH_C.
 IPR014026; UDP-Glc/GDP-Man_DH_dimer.
 IPR001732; UDP-Glc/GDP-Man_DH_N. 
Pfam
 PF00984; UDPG_MGDP_dh
 PF03720; UDPG_MGDP_dh_C
 PF03721; UDPG_MGDP_dh_N 
SMART
 SM00984; UDPG_MGDP_dh_C 
PROSITE
  
PRINTS