CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013695
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PCI domain-containing protein 2 
Protein Synonyms/Alias
 CSN12-like protein 
Gene Name
 PCID2 
Gene Synonyms/Alias
 HT004 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
126NADQQLVKKGKSKVGubiquitination[1]
199AIDSSNLKDDYSTAQubiquitination[1]
211TAQRVTYKYYVGRKAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). 
Sequence Annotation
 DOMAIN 277 388 PCI.
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 399 AA 
Protein Sequence
MRLTDVVQQL VYEAIDSRDG ASCAELVSFK HPHVANPRLQ MASPEEKCQQ VLEPPYDEMF 60
AAHLRCTYAV GNHDFIEAYK CQTVIVQSFL RAFQAHKEEN WALPVMYAVA LDLRVFANNA 120
DQQLVKKGKS KVGDMLEKAA ELLMSCFRVC ASDTRAGIED SKKWGMLFLV NQLFKIYFKI 180
NKLHLCKPLI RAIDSSNLKD DYSTAQRVTY KYYVGRKAMF DSDFKQAEEY LSFAFEHCHR 240
SSQKNKRMIL IYLLPVKMLL GHMPTVELLK KYHLMQFAEV TRAVSEGNLL LLHEALAKHE 300
AFFIRCGIFL ILEKLKIITY RNLFKKVYLL LKTHQLSLDA FLVALKFMQV EDVDIDEVQC 360
ILANLIYMGH VKGYISHQHQ KLVVSKQNPF PPLSTVC 397 
Gene Ontology
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:2000117; P:negative regulation of cysteine-type endopeptidase activity; IMP:UniProtKB.
 GO:0045579; P:positive regulation of B cell differentiation; IEA:Compara.
 GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IMP:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0043488; P:regulation of mRNA stability; IMP:UniProtKB.
 GO:0048536; P:spleen development; ISS:UniProtKB. 
Interpro
 IPR013143; PAM.
 IPR000717; PCI_dom. 
Pfam
 PF01399; PCI 
SMART
 SM00753; PAM 
PROSITE
  
PRINTS